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8

Researchers discover gene that helps control the production of stomach acid

sea-maid submitted, created time 3 weeks 5 days (www.eurekalert.org)

University of Cincinnati (UC) researchers have discovered a gene that helps control the secretion of acid in the stomach—information that could one day aid scientists in creating more efficient treatment options for conditions such as acid reflux or peptic ulcers

7

Yeast reveals sexual selection in action

sea-maid submitted, created time 1 month 2 weeks (www.nature.com)

The yeast microbe provides way to track evolution gene by gene.

Sexual selection is difficult to work with in complex species. Scientists dispute over whether sexually favored traits represent side effects of healthy immune systems or other desirable traits or whether these preferences arise arbitrarily. One of the reasons that this is so difficult to figure out is that the traits involve multiple genes.

7

Gene surveys identify schizophrenia triggers

sea-maid submitted, created time 4 months 12 hours (www.nature.com)

Rare genetic changes associated with a heightened risk of schizophrenia have been revealed by two independent studies.

The surveys have identified sections of the human genome that, when deleted, can elevate the risk of developing schizophrenia by up to fifteen times compared with the general population.

6

"Junk" RNA may play a role in vertebrate evolution

sumsung submitted, created time 9 months 2 weeks (www.sciam.com)

Genetic material once dismissed as mere "junk" may in fact be responsible to the evolution of simple invertebrates into more complex organisms sporting backbones, according to a new study.

5

Drug addiction genes identified

sumsung submitted, created time 10 months 2 weeks (ca.reuters.com)

Scientists in China have identified about 400 genes that appear to make some people more easily addicted to drugs, opening the way for more effective therapies and addiction control.

5

UT rheumatologists discover 2 genes related to disabling form of arthritis

zibba submitted, created time 1 year 1 month (publicaffairs.uth.tmc.edu)

Work done in part by researchers at the University of Texas Medical School at Houston has led to the discovery of two genes that cause ankylosing spondylitis, an inflammatory and potentially disabling disease. The findings are published in the Oct. 21 online edition of Nature Genetics, a journal that emphasizes research on the genetic basis for common and complex diseases.

7

Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST–REST complex

william submitted, created time 1 year 1 month (www.pnas.org)

A preeminent phenotype of the infected cell protein 0 (ICP0) of herpes simplex virus 1 (HSV-1) is that it acts as a promiscuous transactivator. In most cell lines exposed to ΔICP0 mutant virus at low ratios of virus per cell infection, α genes are expressed but the transition to β and γ gene expression does not ensue, but can be enhanced by inhibitors of histone deacetylases (HDACs).

6

Genes that both extend life and protect against cancer identified

franklin submitted, created time 1 year 1 month (www.eurekalert.org)

A person is 100 times more likely to get cancer at age 65 than at age 35. But new research reported today in the journal Nature Genetics identifies naturally occurring processes that allow many genes to both slow aging and protect against cancer in the much-studied C. elegans roundworm.

7

New molecules discovered that block cancer cells from modifying cell DNA

lewis submitted, created time 1 year 1 month (www.eurekalert.org)

Researchers have discovered new small molecules that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in the development of new diagnostic tests and cancer medications.

6

Analysis of breast and colon cancer genes finds many areas of differences between tumors

kitty submitted, created time 1 year 1 month (www.eurekalert.org)

Researchers from University Hospitals Ireland Cancer Center and Case Western Reserve University School of Medicine are part of a new national study that has analyzed more than 18,000 genes, including 5,000 previously unmapped genes, from breast and colorectal tumors. The study shows a great number of genetic differences between breast and colon cancer tumors, leading the researchers to conclude that new drugs must be developed that can hit these newly identified genetic targets in a manner specific to each different individual's tumor.

6

Stem cell nuclei are soft 'hard drives,' Penn study finds

stephen submitted, created time 1 year 1 month (www.eurekalert.org)

Biophysicists at the University of Pennsylvania have discovered that the nuclei of human stem cells are particularly soft and flexible, rather than hard, making it easier for stem cells to migrate through the body and to adopt different shapes, but ultimately to put human genes in the correct nuclear "sector" for proper access and expression.

9

'Network' approach identifies potential breast cancer susceptibility gene

jimmy submitted, created time 1 year 1 month (www.eurekalert.org)

Like a crossword-puzzle solver who uses the letters in some answers to figure out others, researchers at Dana-Farber Cancer Institute and an international group of collaborators have used data on genes involved in inherited forms of breast cancer to identify a gene linked to non-hereditary cases of the disease.

9

Researchers find new gene linked to breast cancer

bianjie submitted, created time 1 year 1 month (www.eurekalert.org)

Researchers in a multicenter international study have identified a new gene that, if mutated, may increase a woman's risk of breast cancer by more than a third.

6

Loss of gene leads to protein splicing and buildup of toxic proteins in neurons

sumsung submitted, created time 1 year 2 months (www.mayoclinic.org)

Researchers at Mayo Clinic in Jacksonville have discovered how loss of a gene can lead to accumulation of toxic proteins in the brain, resulting in a common dementia, and they say this mechanism may be important in a number of age-related neurological disorders.

8

UT Southwestern researchers identify hundreds of genes controlling female fertility

jimmy submitted, created time 1 year 2 months (www.eurekalert.org)

Researchers at UT Southwestern Medical Center have found nearly 350 genes related to female fertility. Their research may open the door to much wider study in the poorly understood field of infertility.

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