Using ChIP-chip technology to reveal common principles of transcriptional repression in normal and cancer cells

sea-maid submitted, created time 8 months 1 week (www.genome.org)

In this paper, the authors performed chromatin immunoprecipitation using antibodies to H3me3K27, H3me3K9, 5-methyl-cytosine, and POLR2A. And then they found that (1) the percentage of low expressed genes bound by POLR2A, H3me3K27, H3me3K9, or 5-methyl-cytosine is similar in all 12 cell types, regardless of differentiation or neoplastic state; (2) a gene is generally repressed by only one mechanism; and (3) distinct classes of genes are repressed by certain mechanisms

1 comment | Blog It | Email It | Keywords: gene expression chromatin silening gene chip transcriptional repression

caGEDA: a web application for the integrated analysis of global gene expression patterns in cancer.

Gene chip helps doctor target cancer treatment

DanyC submitted, created time 1 year 3 months (www.reutershealth.com)

It looked bad for Chuck Fleming -- lung cancer had spread through his body. But his oncologist decided to try using a "gene chip" to see which out of a laundry list of chemotherapy options might work best

1 comment | Blog It | Email It | Keywords: gene chip lung cancer cancer spread

Finding goes boldly into genetic frontiers

julie submitted, created time 1 year 7 months (feeds.feedburner.com)

"Researchers have figured out how to spot genetic changes in the body that may help determine whether a tumor is shrinking or a drug is working, using standard imaging techniques."

Submit comment | Blog It | Email It | Keywords: genetic change tumor gene chip