Novel drug discovery and molecular biological methods, via DNA, RNA and protein changes using structure–function transitions: Transitional structural chemogenomics, transitional structural nucleic acid microarray

DNAMENYIT submitted, created time 1 year 4 months (iris.nyit.edu)

Nucleic acids and proteins are dynamic molecules that undergo structural changes which control gene expression. The authors have developed two novel techniques, viz., transitional structural chemogenomics and
transitional structural chemoproteomics. Transitional structural chemogenomics is used to regulate gene expression, employing ultrasensitive small-molecule drugs targeted toward nucleic acids. Gene expression can be regulated by
using chemicals to target transitional changes in the helical conformations of single-stranded (ss-) and double-stranded (ds-) DNA (e.g

4 comments | Blog It | Email It | Keywords: RNA, DNA,GENE single-stranded DNA gene expression microarrays RNA-DNA hybrid stability gene expression microarray Nuclear Gene Expression gene expression profile RNA, DNA,GENE Single-Stranded DNA gene expression microarrays RNA-DNA hybrid stability gene expression microarray Nuclear Gene Expression gene expression profile

New data on robustness of gene expression signatures in leukemia: comparison of three distinct total RNA preparation procedures

annatto submitted, created time 1 year 6 months (www.biomedcentral.com)

"The signatures in the different subtypes of leukemias, regardless of the different extraction methods used, account for the biggest source of variation in the data. Lysis of mononuclear cells, followed by lysate homogenization and RNA extraction represents the optimum method for robust gene expression data and is thus recommended for obtaining robust classification results in microarray studies in acute leukemias."

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Mouse maps of gene expression in the brain

annatto submitted, created time 1 year 7 months (genomebiology.com)

"The completion of the Allen Brain Atlas generated a great deal of press interest and enthusiasm from the research community. What does it do, and what other complementary resources increase its functionality?....."

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Disturbed Diurnal Rhythm Alters Gene Expression and Exacerbates Cardiovascular Disease With Rescue by Resynchronization

medal submitted, created time 1 year 7 months (hyper.ahajournals.org)

"Day/night rhythms are recognized as important to normal cardiovascular physiology and timing of adverse cardiovascular events; however, their significance in disease has not been determined.
Our study establishes the importance of diurnal rhythm as a vital determinant in heart disease. Disrupted rhythms contribute to progression of organ dysfunction; restoration of normal diurnal schedules appears to be important for effective treatment of disease. "

Submit comment | Blog It | Email It | Keywords: cardiac hypertrophy renin–angiotensin–aldosterone system pat remodeling gene expression microarrays circadian