Application of siRNA Library in High-Throughput Genetic Screens of Mammalian Cells

MedUnion submitted, created time 1 year 8 months (www.mupnet.com)

Small interfering (si)RNA directs gene-specific silencing in both model organisms and mammalian cells through RNA interference. The discovery of this phenomenon has provided a valuable tool to study loss-of-function phenotype of gene. The most recent breakthrough in the generation of large-scale mammalian siRNA libraries further moves forward the application of RNA interference, providing a powerful platform to carry out phenotype-based large-scale genome-wide screen in mammalian cells

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