Articles with the keyword: 
Study shows more genes are controlled by biological clocks
sea-maid submitted, created time 2 months 2 weeks (esciencenews.com)
The tick-tock of your biological clock may have just gotten a little louder. Researchers at the University of Georgia report that the number of genes under control of in living things than suspected only a few years ago. The biological clock in a much-studied model organism is dramatically higher than previously reported. The new study implies that the clock may be much more important. 
davidd submitted, created time 7 months 2 weeks (www.pnas.org)
Small RNAs (21–24 nt) are involved in gene regulation through translation inhibition, mRNA cleavage, or directing chromatin modifications. At least five classes of these small regulatory RNAs (21–24 nt) have been characterized. miRNA and siRNA is reported frquently. However, the natural antisense miRNAs (nat-miRNAs) have not been reported in any system.
Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect
davidd submitted, created time 8 months 2 weeks (nar.oxfordjournals.org)
This may be the first example in which the off-target effect of an siRNA is actually responsible for the anticipated effect by acting to reduce expression of a protein (TNFR1) that normally regulates expression of the intended target (ICAM-1).
davidd submitted, created time 9 months 3 weeks (www.cancercell.org)
The Rb/E2F pathway regulates the expression of genes essential for cell proliferation but that also trigger apoptosis. During normal proliferation, PI3K/Akt signaling blocks E2F1-induced apoptosis, thus serving to balance proliferation and death. They now identify a subset of E2F1 target genes that are specifically repressed by PI3K/Akt signaling, thus distinguishing the E2F1 proliferative or apoptotic function.
Study details regulation of vital tumor suppressor gene p53
lewis submitted, created time 1 year 2 months (www.eurekalert.org)
So vital is the p53 tumor suppressor gene in controlling cancer that its dysfunction is linked to more than half of human cancers. Now, a just-published study reveals new levels of subtlety in the body's management of this all-important tumor suppressor gene and the protein it produces.
captainclaw submitted, created time 1 year 4 months (www.biomedcentral.com)
"Conclusions The results obtained in this study confirm and extend our previous observation that GH is an important regulator of hepatic CD36, and depending on the mode of treatment the gene might be either induced or repressed. We suggest that the effects of continuous GH secretion in females (which is stimulatory) and intermittent GH secretion in males (which is inhibitory) explains the sex-different expression of this gene. Furthermore, a female-specific repression of hepatic CD36 in response to food deprivation was found, which was in contrast to a stimulatory effect in skeletal muscle
angelfish submitted, created time 1 year 4 months (genomebiology.com)
"Elucidation of Plasmodium mRNA decay rates provides a key element for deciphering mechanisms of genetic control in this parasite, by complementing and extending previous mRNA abundance studies. Their results indicate that progressive stage-dependent decreases in mRNA decay rate function are a major determinant of mRNA accumulation during the schizont stage of intraerythrocytic development
Molecular and Cellular Biology
saury submitted, created time 1 year 4 months (mcb.asm.org)
"This studies indicate that about one-third of these direct E2 target genes contain promoter-proximal ER{alpha}-binding sites, which is considerably more than previous estimates. Some of these genes represent possible novel targets for regulation through the ER{alpha}/AP-1 tethering pathway. Their studies have also revealed several previously uncharacterized global features of E2-regulated gene expression, including strong positive correlations between Pol II occupancy and AcH levels, as well as between the E2-dependent recruitment of ER{alpha} and SRC at the promoters of E2-stimulated genes
Agricultural applications for transgenic livestock
medal submitted, created time 1 year 6 months (www.sciencedirect.com)
"Transgenic animals are produced by introducing ‘foreign’ DNA into the genetic material of pre-implantation embryos. This DNA is present in all tissues of the resulting individual. This technique is of great importance to many aspects of biomedical science, including gene regulation, the immune system, cancer research, developmental biology, biomedicine, manufacturing and agriculture. The production of transgenic animals is one of several new and developing technologies that will have a profound impact on the genetic improvement of livestock
Dose Response Relationship in Anti-Stress Gene Regulatory Networks
cappuccion submitted, created time 1 year 8 months (compbiol.plosjournals.org)
To maintain a stable intracellular environment, cells are equipped with multiple specialized defense programs that are launched in response to various external chemical and physical stressors. These anti-stress mechanisms comprise primarily gene regulatory networks, and like many manmade control devices, such as thermostats and automobile cruise controls, they are often organized into negative feedback circuits
Identification of the Ligands of Protein Interaction Domains through a Functional Approach
saury submitted, created time 1 year 8 months (www.mcponline.org)
“Small GTPase RAS plays a critical role in cellular signaling and oncogenic transformation. Proteomics analysis of genetically defined human ovarian cancer models identified the tumor susceptibility gene 101 (TSG101) as a downstream target of RAS oncogene. Mechanistic studies revealed a novel post-translational regulation of TSG101 through the RAS/RAF/MEK/MAPK signaling pathway and downstream molecules p14ARF/HDM2. Immunoanalysis using ovarian cancer samples and microtissue array revealed elevated TSG101 levels in human ovarian carcinomas
Scarlett submitted, created time 1 year 8 months (www.biomedcentral.com)
Protein identification showed that functionally related polypeptides (isoforms and complex subunits) could be differentially regulated in synthetic B. napus in comparison to its diploid progenitors while such proteins are usually expected to display co-regulation. The genetic redundancy within an allopolyploid could explain why functionally related proteins could display imbalanced levels of expression
A Factor analysis for gene regulatory networks and transcription factor activity profiles
Rhett submitted, created time 1 year 8 months (www.biomedcentral.com)
Many algorithms for the inference of the structure of gene regulatory networks from gene expression data assume that the activity levels of transcription factors (TFs) are proportional to their mRNA levels, which assumption is invalid for most biological systems. However, one might be able to reconstruct unobserved activity profiles of TFs from the expression profiles of target genes. A simple model is a two-layer network with unobserved TF variables in the first layer and observed gene expression variables in the second layer. TFs are connected to regulated genes by weighted edges
\ 1
\ 
abuse@discover8.com
Darkfrog
kavin
Sue Wu
DanyC
jane2007
addict
Human umbilical vein; 250 ug/250 ul.
www.genscript.com
SK-BR3
Human breast carcinoma; 250 ug/250 ul.
www.genscript.com
Western Optimization Kit (Mouse)
Kit : Western Optimization Kit (Mouse)
www.genscript.com
Rabbit Anti p44/42 MAP Kinase (Phospho-Thr202) (Polyclonal)
antibody : Rabbit Anti p44/42 MAP Kinase (Phospho-Thr202) (P ...
www.genscript.com