Articles with the keyword: 
Silencing Growth Inhibitors Could Help Recovery from Brain Injury
sea-maid submitted, created time 3 weeks 1 day (gopast.net)
Silencing natural growth inhibitors may make it possible to regenerate nerves damaged by brain or spinal cord injury, finds a study from Children's Hospital Boston. In a mouse study published in the November 7 issue of Science, researchers temporarily silenced genes that prevent mature neurons from regenerating, and caused them to recover and re-grow vigorously after damage. 
Gene silencing made practical: siRNA used to treat neurogenerative disorders in the lab
Darkfrog submitted, created time 5 months 3 weeks (www.jbc.org)
This abstract is about as easy to read as sixteenth-century tax law, but here's the gist: Human neurogenerative disorders, like Huntington's, Parkinson's, Alzheimer's and amyotrophic lateral sclerosis (Lou Gherig's disease) are all caused or exacerbated by the expression of mutant genes. If we switch off the genes--or at least keep them from producing proteins--then the patients might get better. One way to switch off a gene is to inject the cell with a siRNA (short interfering RNA) that complements the gene's product mRNA. This is called gene silencing
Triumphs and tribulations for RNA interference
jane2007 submitted, created time 8 months 5 days (www.nature.com)
Two studies highlight promise and problems for gene silencing technique. Researchers could offer a new way by microRNA interference to treat conditions from cancer to cardiovascular disease. But another study shows that the effects of RNAi on genes involved in a severe form of blindness called age-related macular degeneration (AMD). In this case RNAi-causing drugs have already gone into trials. It isn't that the drugs don't work; it's that they work no matter what siRNA sequence is used. This brings the current understanding of the mechanism of RNA interference into question.
Homing in on the Silenced Gene Behind Mental Retardation
yangjane submitted, created time 1 year 2 weeks (www.sciam.com)
In humans, the disorder stems from a mutation on the X chromosome as a three-base sequence begins to repeat over and over in a section of the fragile X mental retardation 1 gene (FMR1). The portion of the gene where this error multiplies does not code for a protein, which means that several repetitions of the sequence can occur without damaging the fragile X mental retardation protein (FMRP). People who have a gene with a sequence that is repeated 50 or fewer times are considered normal; those with fewer than 200 repetitions are carriers of the disorder
Newly Identified Mechanism For Silencing Genes Points To Possible Anti-Cancer Strategies
Dolly submitted, created time 1 year 6 months (www.medicalnewstoday.com)
In a new study published online May 16 in the journal Nature, a team of scientists at The Wistar Institute and the University of California, San Diego, report identification of an important new gene-silencing mechanism, one that blocks the cellular machinery responsible for translating messenger RNA into proteins at specific genes.
Application of siRNA Library in High-Throughput Genetic Screens of Mammalian Cells
MedUnion submitted, created time 1 year 7 months (www.mupnet.com)
Small interfering (si)RNA directs gene-specific silencing in both model organisms and mammalian cells through RNA interference. The discovery of this phenomenon has provided a valuable tool to study loss-of-function phenotype of gene. The most recent breakthrough in the generation of large-scale mammalian siRNA libraries further moves forward the application of RNA interference, providing a powerful platform to carry out phenotype-based large-scale genome-wide screen in mammalian cells
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