Articles with the keyword: 
Ark floats gene therapy's boat, for now
sea-maid submitted, created time 1 month 5 days (www.nature.com)
In August, gene therapy's turbulent ride through the clinical rapids took a new twist as Ark Therapeutics released positive top-line results from a phase 3 trial of its adenoviral gene therapy Cerepro (sitimagene ceradenovec) for malignant brain tumors. Although the news boosted the London-based firm's shares, the course to market authorization and registration remains strewn with uncertainty—as Introgen, of Austin, Texas, found, to its cost, when the U.S 
Gene Therapy Offers Hope for Blindness
sea-maid submitted, created time 1 month 2 weeks (www.webmd.com)
After more than a decade of research, the first gene therapy trials in people with a rare form of blindness are under way, and experts say they are thrilled with the early findings.
Gene therapy tool would target free radicals
sea-maid submitted, created time 2 months 1 day (www.sciencenews.org)
Gene therapy has been touted as a possible way to cure genetic diseases, but new research suggests that it could also fight the wear and tear that leads to cardiovascular diseases.
ScienceNews reports:
"To work within this delicate balance, researchers in Finland have developed a way to insert into human cells free radical–fighting genes that only get switched on when free radical concentrations are high. That way, the genes could stave off the worst effects of free radicals without inhibiting the molecules’ useful functions, the researchers report in the September Gene Therapy."
Gene therapy experiments improve vision in nearly blind
sea-maid submitted, created time 3 months 14 hours (www.newsvine.com)
Scientists for the first time have used gene therapy to dramatically improve sight in people with a rare form of blindness, a development experts called a major advance for the experimental technique. Four of the six patients regained some vision.
DNA scissors enhance gene therapy ...now available to all comers
jerry submitted, created time 4 months 6 days (sciencenow.sciencemag.org)
Imagine you're trying to find a cure for a disease, such as cystic fibrosis, which results from a single defective gene. Using traditional gene therapy, you'd infect the patient with a virus containing a good copy of the gene, hoping the DNA inserts into the person's genome in a spot that doesn't trigger cancer.
"There's got to be a better way," you tell yourself--and there is. About a decade ago, researchers began developing a new strategy that relies on proteins called zinc finger nucleases that bind to a very specific place on a chromosome
UGA research may lead to safer, more effective gene therapy
sea-maid submitted, created time 5 months 4 days (esciencenews.com)
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps...
sea-maid submitted, created time 6 months 3 days (www.jcb.org)
Interest in satellite cells exploded in the last four years. The work may lead to basic insights into the nature of quiescence, self-renewal and differentiation (Conboy et al., 2003), and help identify the best cell type for use in gene therapy applications.
the construction of gene therapy for blood disorders
sea-maid submitted, created time 7 months 5 days (bloodjournal.hematologylibrary.org)
The concept of introducing genes into human cells for therapeutic purposes developed nearly 50 years ago as diseases due to defects in specific genes were recognized. The development history of gene therapy for blood disorders was introduced in this paper.
Triumphs and tribulations for RNA interference
jane2007 submitted, created time 8 months 5 days (www.nature.com)
Two studies highlight promise and problems for gene silencing technique. Researchers could offer a new way by microRNA interference to treat conditions from cancer to cardiovascular disease. But another study shows that the effects of RNAi on genes involved in a severe form of blindness called age-related macular degeneration (AMD). In this case RNAi-causing drugs have already gone into trials. It isn't that the drugs don't work; it's that they work no matter what siRNA sequence is used. This brings the current understanding of the mechanism of RNA interference into question.
Sue Wu submitted, created time 8 months 1 week (www.sciencedaily.com)
Individuals with a number of life-threatening genetic diseases of the immune system have been successfully treated by gene therapy
-- that is, they were infused with early precursors of immune cells that had the correct form of the defective gene delivered into them by agents known as retroviral vectors. However, many of them also developed leukemia.
Gene Therapy Could Cure GSD-Ia
Sue Wu submitted, created time 8 months 2 weeks (www.dukemednews.org)
A gene therapy treatment that restores a missing liver enzyme in test animals could provide a cure for a rare metabolic disorder in humans, according to Duke University Medical Center researchers.
Fatal brain cancer tamed by gene therapy
DanyC submitted, created time 9 months 6 days (www.newscientist.com)
Rats with an aggressive form of human brain cancer have been successfully treated with gene therapy.
davidd submitted, created time 9 months 2 weeks (www.nature.com)
The article represents adeno-associated virus vectors optimiztion for potential application in future hemophilia B clinical trials and liver-directed gene delivery.
These studies underscore the need for rigorous analysis and optimization of vector genome cassettes.
New Gene Therapy Eliminates Chronic Pain
Sue Wu submitted, created time 10 months 1 week (www.redorbit.com)
Researchers at Mount Sinai School of Medicine were able to eliminate chronic pain for at least three months in rats who were given spinal injections of a new gene therapy that triggers the body’s natural pain killer endorphin.
Gene Therapy Cancers Prompt Design of Safer Virus
Eric wu submitted, created time 10 months 3 weeks (sciencenow.sciencemag.org)
The announcement last month that a fifth child who received gene therapy for an immune system disease has developed leukemia was the latest blow to the field of gene therapy. But there's new hope: The U.K. team running the trial reports this week that a safer formulation of the treatment can cure the disease in mice and should also work in people.
This may be a new angle to prove security of gene therapy......
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