Articles with the keyword: 
Combined Stem Cell-Gene Therapy Approach Cures Human Genetic Disease In Vitro
piggy submitted, created time 9 months 1 week (www.sciencedaily.com)
A study led by researchers at the Salk Institute for Biological Studies, has catapulted the field of regenerative medicine significantly forward, proving in principle that a human genetic disease can be cured using a combination of gene therapy and induced pluripotent stem (iPS) cell technology. The study is a major milestone on the path from the laboratory to the clinic. 
Gene Therapy Could Expand Stem Cells' Promise
piggy submitted, created time 9 months 2 weeks (news.med.cornell.edu)
Once placed into a patient's body, stem cells intended to treat or cure a disease could end up wreaking havoc simply because they are no longer under the control of the clinician.
But gene therapy has the potential to solve this problem, according to a perspective article from physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center published in a recent issue of the journal Cell Stem Cell. The paper details strategies for genetically modifying stem cells prior to transplantation in order to ensure their safety.
Boosting its infectivity turns benign virus into good gene therapy carrier for cystic fibrosis
piggy submitted, created time 1 year 3 weeks (www.eurekalert.org)
Researchers from the University of California, Berkeley, and the University of Iowa have turned a relatively benign virus into a highly infectious form that is ideal as a carrier for gene therapy. In its first gene therapy test, it completely cured human cystic fibrosis lung tissue in culture
Newly found enzymes may play early role in cancer
piggy submitted, created time 1 year 2 months (www.eurekalert.org)
Researchers have discovered two enzymes that, when combined, could be involved in the earliest stages of cancer. Manipulating these enzymes genetically might lead to targeted therapies aimed at slowing or preventing the onset of tumors.
"We could conceivably reactivate a completely normal gene in a tumor cell – a gene that could prevent the growth of a tumor if reactivated," says David Jones, Ph.D., professor of oncological sciences at the University of Utah and senior director of early translational research at the university's Huntsman Cancer Institute (HCI)
Researchers identify new anti-tumor gene
piggy submitted, created time 1 year 2 months (www.eurekalert.org)
Researchers from Virginia Commonwealth University have identified a new anti-tumor gene called SARI that can interact with and suppress a key protein that is overexpressed in ninety percent of human cancers. The discovery could one day lead to an effective gene therapy for cancer.
According to Paul B. Fisher, M.Ph., Ph.D
Gene may open door for new sickle cell therapies
piggy submitted, created time 1 year 3 months (www.reuters.com)
U.S. researchers have discovered a gene switch that could lead to better treatments for sickle cell disease and thalassemia, two inherited blood disorders that affect millions of people, they said on Thursday.
Learning how to activate this switch might help doctors direct the body to make healthier blood cells -- in this case, replicating conditions found in the womb.
People with these blood disorders either make too little or abnormal forms of hemoglobin, the protein in red blood cells that is vital for carrying oxygen to the body's tissues
Gene Therapy Offers Hope for Blind people
sea-maid submitted, created time 1 year 3 months (www.pnas.org)
Human gene therapy for a severe form of inherited blindness is showing promise, researchers report.
Ark floats gene therapy's boat, for now
sea-maid submitted, created time 1 year 4 months (www.nature.com)
In August, gene therapy's turbulent ride through the clinical rapids took a new twist as Ark Therapeutics released positive top-line results from a phase 3 trial of its adenoviral gene therapy Cerepro (sitimagene ceradenovec) for malignant brain tumors. Although the news boosted the London-based firm's shares, the course to market authorization and registration remains strewn with uncertainty—as Introgen, of Austin, Texas, found, to its cost, when the U.S
Gene Therapy Offers Hope for Blindness
sea-maid submitted, created time 1 year 4 months (www.webmd.com)
After more than a decade of research, the first gene therapy trials in people with a rare form of blindness are under way, and experts say they are thrilled with the early findings.
Gene therapy tool would target free radicals
sea-maid submitted, created time 1 year 5 months (www.sciencenews.org)
Gene therapy has been touted as a possible way to cure genetic diseases, but new research suggests that it could also fight the wear and tear that leads to cardiovascular diseases.
ScienceNews reports:
"To work within this delicate balance, researchers in Finland have developed a way to insert into human cells free radical–fighting genes that only get switched on when free radical concentrations are high. That way, the genes could stave off the worst effects of free radicals without inhibiting the molecules’ useful functions, the researchers report in the September Gene Therapy."
Gene therapy experiments improve vision in nearly blind
sea-maid submitted, created time 1 year 6 months (www.newsvine.com)
Scientists for the first time have used gene therapy to dramatically improve sight in people with a rare form of blindness, a development experts called a major advance for the experimental technique. Four of the six patients regained some vision.
DNA scissors enhance gene therapy ...now available to all comers
jerry submitted, created time 1 year 7 months (sciencenow.sciencemag.org)
Imagine you're trying to find a cure for a disease, such as cystic fibrosis, which results from a single defective gene. Using traditional gene therapy, you'd infect the patient with a virus containing a good copy of the gene, hoping the DNA inserts into the person's genome in a spot that doesn't trigger cancer.
"There's got to be a better way," you tell yourself--and there is. About a decade ago, researchers began developing a new strategy that relies on proteins called zinc finger nucleases that bind to a very specific place on a chromosome
UGA research may lead to safer, more effective gene therapy
sea-maid submitted, created time 1 year 8 months (esciencenews.com)
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps...
sea-maid submitted, created time 1 year 9 months (www.jcb.org)
Interest in satellite cells exploded in the last four years. The work may lead to basic insights into the nature of quiescence, self-renewal and differentiation (Conboy et al., 2003), and help identify the best cell type for use in gene therapy applications.
the construction of gene therapy for blood disorders
sea-maid submitted, created time 1 year 10 months (bloodjournal.hematologylibrary.org)
The concept of introducing genes into human cells for therapeutic purposes developed nearly 50 years ago as diseases due to defects in specific genes were recognized. The development history of gene therapy for blood disorders was introduced in this paper.
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