A global analysis of genetic interactions in Caenorhabditis elegans

june submitted, created time 1 year 3 months (www.sciencedaily.com)

We investigated interactions between 11 'query' mutants in conserved signal transduction pathways and hundreds of 'target' genes compromised by RNA interference (RNAi). Mutant-RNAi combinations that grew more slowly than controls were identified, and genetic interactions inferred through an unbiased global analysis of the interaction matrix. A network of 1,246 interactions was uncovered, establishing the largest metazoan genetic-interaction network to date. We refer to this approach as systematic genetic interaction analysis (SGI)

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Gene–environment correlations: a review of the evidence and implications for prevention of mental illness

penguin submitted, created time 1 year 7 months (www.nature.com)

"Using examples from studies in psychology and psychiatry, we integrate the behavioral and molecular genetic literatures on rGE, describe challenges in identifying rGE and discuss the implications of molecular genetic findings of rGE for future research on gene–environment interplay and for attempts to prevent disease by reducing environmental risk exposure."

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