Articles with the keyword: 
sea-maid submitted, created time 1 week 2 days (www.jcb.org)
Active genes can be sociable, snuggling up to one another. Brown et al. offer a new explanation for this clustering, suggesting that genes gather for the services of RNA splicing enzymes
A gene's location in the nucleus often reflects its activity. Hard-working genes tend to congregate in the interior of the nucleus, whereas their lazier counterparts hang out at the edge. Moreover, active genes on different chromosomes sometimes bunch up. How often active genes come together is uncertain 
A new way to identify disease associated genes
jerry submitted, created time 1 week 6 days (www.biodatamining.org)
A new algorithm, which mines databases of tissue specificity, gene connectivity and disease association, has identified a new group of genes that interact with disease-causing genes and impact on disease outcomes.
New mutant collection examines six thousand genes. Next big thing in drug discovery?
jerry submitted, created time 1 month 4 days (stke.sciencemag.org)
A major challenge in drug discovery is to identify the cellular targets responsible for the pharmacological activity of drug candidates. In the yeast Saccharomyces cerevisiae, a heterozygous diploid mutant collection of approximately six thousand strains, in each of which one copy of a single gene is deleted, is commercially available. With this collection, it is possible to evaluate the role of each gene product in the response of cells to a drug
Study shows more genes are controlled by biological clocks
sea-maid submitted, created time 1 month 5 days (esciencenews.com)
The tick-tock of your biological clock may have just gotten a little louder. Researchers at the University of Georgia report that the number of genes under control of in living things than suspected only a few years ago. The biological clock in a much-studied model organism is dramatically higher than previously reported. The new study implies that the clock may be much more important.
jerry submitted, created time 1 month 3 weeks (sciencenow.sciencemag.org)
How much you smell depends on how often you bathe, but precisely how you smell depends on your genes, a new study suggests. The body odors of identical twins are significantly more similar than the scents of unrelated people, researchers in Switzerland have found. The results could pave the way for new tools to diagnose disease or identify people based on scent.
Body odor emanates from a chemical reaction between bacteria on the skin and sweat, a secretion that itself is odorless
Aging May Be Controlled by Brake and Accelerator Genes
sea-maid submitted, created time 2 months 1 week (www.sciam.com)
Can we tweak certain genes to stave off the aging process—or, conversely, to speed it up? New research indicates that it may one day be possible.
For the present, the current discovery helps to expalin something that the prevailing theory of aging--the idea that our bodies wear out because of errors accumulating in our DNA--cannot: why different species have different lifespans.
Where There's Smoke, There's (Genetic) Fire
jerry submitted, created time 2 months 2 weeks (sciencenow.sciencemag.org)
Peer pressure may push teens to start smoking, but their DNA keeps them hooked on the nicotine buzz into their adult years. So says a new study that finds that people with variations in particular genes are more likely to become addicted if they start smoking during early adolescence. The work may explain why some people find it harder to kick the habit and also underscores the importance of preventing children from smoking in the first place.
HIV gene is a mixed blessing for carriers
sea-maid submitted, created time 2 months 2 weeks (www.newscientist.com)
A GENETIC mutation common in African Americans slows the progression of HIV, yet paradoxically increases the risk of contracting the virus in the first place.
A clue that race-specific genes are involved in HIV came in 2002, when Sunil Ahuja of the University of Texas Health Science Center in San Antonio and colleagues discovered a mutation in the CCL5 gene that accelerates the progression of HIV-1, the most common form of the virus. Though the mutation was found in people of all races, it only accelerated the disease in Americans of European descent
New Gene for Alzheimer's Discovered
lily1984 submitted, created time 3 months 1 week (www.bloomberg.com)
Scientists have discovered a gene that raises the risk of late-onset Alzheimer's disease by as much as 77 percent and provides scientists with a second genetic target for developing new treatments for the disorder.
One copy of the gene, called calcium homeostasis modulator 1, or CALHM1, increases the likelihood of late-onset Alzheimer's by 44 percent, while two copies boost the risk 77 percent. About a quarter of the population has one copy, said study author Philippe Marambaud from the Albert Einstein College of Medicine in New York. The research was published in the journal Cell
A Genetic Clue to Quitting Smoking
jerry submitted, created time 4 months 3 days (www.time.com)
A blood test may one day be able to predict how a smoker will respond to two popular methods of kicking the habit... Nicotine replacement, like gums and patches, wean the smoker off nicotine gradually, but Zyban, an antidepressant, works to fight nicotine cravings in the person's brain. Some people respond much better to one strategy or the other.
sea-maid submitted, created time 4 months 1 week (genomebiology.com)
Several genes implicated in food digestion have been deleted or inactivated in platypus. This loss perhaps explains the anatomical and physiological differences in the gastrointestinal tract between monotremes and other vertebrates and provides insights into platypus genome evolution.
Sue Wu submitted, created time 4 months 3 weeks (www.nzherald.co.nz)
A gene that significantly increases the risk of asthma in children has been discovered by British scientists who described it as the strongest link yet in the search to find a genetic basis for the condition.
Genetic interaction with smoking in arthritis
jerry submitted, created time 4 months 4 weeks (arthritis-research.com)
Analysis of data from a study of American nurses confirms the PTPN22 polymorphism is a strong risk factor for rheumatoid arthritis, and that its presence interacts multiplicatively with heavy smoking.
Environmental and genetic modifiers of the progression to fibrosis and cirrhosis in hemochromatosis
sea-maid submitted, created time 5 months 1 week (bloodjournal.hematologylibrary.org)
Hemochromatosis is a disease related to a relatively common and easily identifiable genetic defect, but the extent of clinical expression is variable and to a large extent remains unexplained. But this review explores recent developments in knowledge of environmental and genetic modifiers of this process.
Effect of Variation in CHI3L1 on Serum YKL-40 Level, Risk of Asthma, and Lung Function
davidd submitted, created time 5 months 3 weeks (content.nejm.org)
This study shows an association between markers in the gene encoding YKL-40 and asthma, indicating that YKL-40 levels not only serve as a biomarker but also contribute to disease susceptibility.
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