Genetic Variant Raises HIV Risk

sea-maid submitted, created time 4 months 1 week (www.time.com)

There's no doubt Africans have borne the brunt of the AIDS epidemic. Now researchers in London and Texas say it may have something to do with a single gene variant that could account for 11%, or about 2.5 million, of Africa's HIV cases.

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Lung Cancer Genes Identified

New Insight Into The Link Between Genetics And Obesity

searcher submitted, created time 1 year 3 weeks (www.sciencedaily.com)

Their findings, reported online today in Science Express, could have implications for the future treatment of obesity as well as adult onset diabetes. via Science Daily

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The gene that turns breast-milk into brain food

yangjane submitted, created time 1 year 3 weeks (www.nature.com)

Only if the child carries a version of a gene that can harness the goodness of breast-milk, say researchers.

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New genetic variant associated with prostate cancer in African-Americans

carly submitted, created time 1 year 1 month (www.eurekalert.org)

Two tiny genetic variations may provide the best clues yet for finding more precise ways to estimate prostate cancer risk and improve screening and early detection for men of African descent.

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Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans

franklin submitted, created time 1 year 1 month (www.pnas.org)

The low barometric pressure at high altitude causes lower arterial oxygen content among Tibetan highlanders, who maintain normal levels of oxygen use as indicated by basal and maximal oxygen consumption levels that are consistent with sea level predictions.

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Characterization of mutation spectra with ultra-deep pyrosequencing: Application to HIV-1 drug resistance

captainclaw submitted, created time 1 year 5 months (www.genome.org)

"The detection of mutant spectra within a population of microorganisms is critical for the management of drug-resistant infections. Researchers performed ultra-deep pyrosequencing to detect minor sequence variants in HIV-1 protease and reverse transcriptase (RT) genes from clinical plasma samples. They estimated empirical error rates from four HIV-1 plasmid clones and used them to develop a statistical approach to distinguish authentic minor variants from sequencing errors in eight clinical samples

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A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

daphne submitted, created time 1 year 5 months (www.sciencemag.org)

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genotyped 1161 Finnish T2D cases and 1174 Finnish normal glucose-tolerant (NGT) controls with >315,000 single-nucleotide polymorphisms (SNPs) and imputed genotypes for an additional >2 million autosomal SNPs.

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First confirmed common genetic risk factors for breast cancer

julie submitted, created time 1 year 6 months (www.biologynews.net)

"The most powerful genetic analysis of the DNA codes of over 40,000 women -- including those with breast cancer as well as those without the disease – has uncovered five common genetic variants that increase an individual’s risk for breast cancer."

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