Why Some Smokers Get Lung Cancer--And Others Are Spared

Risk genes for multiple sclerosis uncovered

bianjie submitted, created time 1 year 5 months (www.eurekalert.org)

Using a whole-genome association scan, an international consortium of scientists has found genetic variations in multiple sclerosis patients, findings that suggest a possible link between MS and other autoimmune diseases.

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New research proves single origin of humans in Africa

bianjie submitted, created time 1 year 5 months (www.eurekalert.org)

New research published in the journal Nature July 19 has proved the single origin of humans theory by combining studies of global genetic variations in humans with skull measurements across the world. The research, at the University of Cambridge and funded by the Biotechnology and Biological Sciences Research Council, represents a final blow for supporters of a multiple origins of humans theory.

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Study finds hereditary link to premenstrual depression

bianjie submitted, created time 1 year 5 months (www.eurekalert.org)

A specific genetic variation may be tied to an increased risk for severe premenstrual depression, scientists at the University of North Carolina at Chapel Hill and the National Institute of Mental Health have found.

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Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity

captainclaw submitted, created time 1 year 5 months (www.biomedcentral.com)

"SGNE1 genetic variation does not contribute to obesity and common forms of T2D but may worsen glucose intolerance and insulin resistance, especially in the background of severe and early onset obesity. Further molecular studies are required to understand the molecular bases involved in this process."

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Which common genetic variation is linked to heart attack ?

crackpot submitted, created time 1 year 8 months (english.people.com.cn)

Researchers found individuals with the variation have a 1.64-fold greater risk of suffering a heart attack (myocardial infarction) and a 2.02-fold greater risk of suffering a heart attack early in life (before age 50 for men and before age 60 for women) than those without the variation. This study was now project led by the Icelandic genomics company deCODE Genetics, along with U.S. researchers at Emory University School of Medicine, Duke University, and the University of Pennsylvania.

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Recent human effective population size estimated from linkage disequilibrium

DanyC submitted, created time 1 year 9 months (www.genome.org)

"Effective population size (Ne) determines the amount of genetic variation, genetic drift, and linkage disequilibrium (LD) in populations. Here, They present the first genome-wide estimates of human effective population size from LD data. Chromosome-specific effective population size was estimated for all autosomes and the X chromosome from estimated LD between SNP pairs

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Are you a pouty woman? And why?

psychologist submitted, created time 1 year 9 months (www.dailybiomed.com)

Ever wonder why some women seem to be more ill-tempered than others? University of Pittsburgh researchers have found that behaviors such as anger, hostility and aggression may be genetic, rooted in variations in a serotonin receptor gene. Aggression and hostility are predictors of hypertension, glucose metabolism and heart diseases. The genetic marker we found for hostility also may be useful for predicting a person's predisposition to such diseases. If you are a ill-tempered one, take care of your body!

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Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization

saury submitted, created time 1 year 9 months (www.genome.org)

“Here the study report the sequencing and analysis of the first chromosome of E. tenella, a chromosome believed to carry loci associated with drug resistance and known to differ between virulent and attenuated strains of the parasite. The chromosome—which appears to be representative of the genome—is gene-dense and rich in simple-sequence repeats, many of which appear to give rise to repetitive amino acid tracts in the predicted proteins

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Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density

Scarlett submitted, created time 1 year 10 months (breast-cancer-research.com)

Mammographic density is one of the strongest risk factors for breast cancer, and is believed to represent epithelial and stromal proliferation. Insulin-like growth factor (IGF) pathway plays an important role in cellular proliferation and breast development. Breast density has high heritability, so it was useful to determine the association between common genetic variation in this pathway and mammographic density. This study proved that common genetic variation in IGF1 is strongly associated with percent mammographic density

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