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7

Discovery of natural compounds that could slow blood vessel growth

sea-maid submitted, created time 1 day 20 hours (esciencenews.com)

Using a whole-genome approach, researchers have found more than one hundred human protein compounds that can slow blood vessel growth. This could lead to treatments against diseases that depend on the growth of new blood vessels, including cancer, macular degeneration and rheumatoid arthritis.

8

X chromosome is extra diverse

sea-maid submitted, created time 6 days 21 hours (www.sciencenews.org)

Men who father children with multiple women are responsible for “extra” diversity on the X chromosome, a new study of six different populations suggests.

5

A new way to identify disease associated genes

jerry submitted, created time 1 week 6 days (www.biodatamining.org)

A new algorithm, which mines databases of tissue specificity, gene connectivity and disease association, has identified a new group of genes that interact with disease-causing genes and impact on disease outcomes.

5

Plants' daily alarm clock discovered

sea-maid submitted, created time 2 weeks 6 days (www.newscientist.com)

A newly discovered family of genes acts as a plant's daily alarm, triggering a growth spurt just before dawn. By tweaking these genes, scientists may one day be able to engineer crops that grow for longer every day to produce bigger yields.

The timing of the growth spurt is known to be choreographed by the plant's circadian clock, which is reset by changes in light at dawn and dusk. The clock dictates when most physiological processes, such as the uptake of water and the breakdown of starch, happen throughout the day

8

Study shows more genes are controlled by biological clocks

sea-maid submitted, created time 1 month 5 days (esciencenews.com)

The tick-tock of your biological clock may have just gotten a little louder. Researchers at the University of Georgia report that the number of genes under control of in living things than suspected only a few years ago. The biological clock in a much-studied model organism is dramatically higher than previously reported. The new study implies that the clock may be much more important.

7

Gene Identified for Deadly Childhood Cancer

sea-maid submitted, created time 1 month 1 week (sciencenow.sciencemag.org)

Fifteen years of genetic sleuthing have finally paid off: Researchers have nailed the gene that appears to cause an inherited form of neuroblastoma, a cancer of the nervous system that predominantly strikes children. Scientists are optimistic that the findings will allow them to develop disease screening for some families, as well as lead to potential new therapies.

11

Gene mutations reveal schizophrenia's complexity

sea-maid submitted, created time 1 month 2 weeks (www.newscientist.com)

The three largest genetic schizophrenia studies to date have uncovered several ways in which changes to the genome may increase the risk of developing the condition.

The studies bring to light several common variations that increase the risk slightly, and rarer ones that raise it significantly, researchers say.

6

Missing DNA Boosts Risk of Schizophrenia

sea-maid submitted, created time 2 months 3 days (sciencenow.sciencemag.org)

Two large studies of schizophrenia patients have yielded the most convincing evidence yet that the disease can be caused by mistakes in genes. The researchers linked a much higher risk for schizophrenia to three chromosomal regions that are missing chunks of DNA. Although only a tiny fraction of patients carried these particular glitches, similar errors may help explain other cases of the disease.

9

Aging May Be Controlled by Brake and Accelerator Genes

sea-maid submitted, created time 2 months 1 week (www.sciam.com)

Can we tweak certain genes to stave off the aging process—or, conversely, to speed it up? New research indicates that it may one day be possible.

For the present, the current discovery helps to expalin something that the prevailing theory of aging--the idea that our bodies wear out because of errors accumulating in our DNA--cannot: why different species have different lifespans.

8

Where There's Smoke, There's (Genetic) Fire

jerry submitted, created time 2 months 2 weeks (sciencenow.sciencemag.org)

Peer pressure may push teens to start smoking, but their DNA keeps them hooked on the nicotine buzz into their adult years. So says a new study that finds that people with variations in particular genes are more likely to become addicted if they start smoking during early adolescence. The work may explain why some people find it harder to kick the habit and also underscores the importance of preventing children from smoking in the first place.

7

HIV gene is a mixed blessing for carriers

sea-maid submitted, created time 2 months 2 weeks (www.newscientist.com)

A GENETIC mutation common in African Americans slows the progression of HIV, yet paradoxically increases the risk of contracting the virus in the first place.

A clue that race-specific genes are involved in HIV came in 2002, when Sunil Ahuja of the University of Texas Health Science Center in San Antonio and colleagues discovered a mutation in the CCL5 gene that accelerates the progression of HIV-1, the most common form of the virus. Though the mutation was found in people of all races, it only accelerated the disease in Americans of European descent

7

Genetic Variant Raises HIV Risk

sea-maid submitted, created time 2 months 2 weeks (www.time.com)

There's no doubt Africans have borne the brunt of the AIDS epidemic. Now researchers in London and Texas say it may have something to do with a single gene variant that could account for 11%, or about 2.5 million, of Africa's HIV cases.

6

New Gene for Alzheimer's Discovered

lily1984 submitted, created time 3 months 1 week (www.bloomberg.com)

Scientists have discovered a gene that raises the risk of late-onset Alzheimer's disease by as much as 77 percent and provides scientists with a second genetic target for developing new treatments for the disorder.

One copy of the gene, called calcium homeostasis modulator 1, or CALHM1, increases the likelihood of late-onset Alzheimer's by 44 percent, while two copies boost the risk 77 percent. About a quarter of the population has one copy, said study author Philippe Marambaud from the Albert Einstein College of Medicine in New York. The research was published in the journal Cell

10

A Genetic Clue to Quitting Smoking

jerry submitted, created time 4 months 3 days (www.time.com)

A blood test may one day be able to predict how a smoker will respond to two popular methods of kicking the habit... Nicotine replacement, like gums and patches, wean the smoker off nicotine gradually, but Zyban, an antidepressant, works to fight nicotine cravings in the person's brain. Some people respond much better to one strategy or the other.

8

Life After Extinction: Is There a Tiger in the Mouse?

jerry submitted, created time 4 months 1 week (www.sciam.com)

Researchers transfer DNA from the long-vanished Tasmanian tiger into a mouse. The finding shows how lost information about species from the past can be retrieved and also provides a glimpse into how long-gone creatures may someday get a second chance at life.

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