Codon evolution is governed by linear formulas.

sorimachi submitted, created time 10 months 3 weeks (www.springerlink.com)

A new discavery that codon evolution is governed by linear formulas based on simple calculations of a lot of genomic data. This study has been dirived from the evidence that a gene assembly coding 3,000-7,000 amino acid residues represents the whole genome (Mycoscience 44(5): 415-417, 2003); genome is constructed homogeneously with putative small units coding similar amino acid compositions.

2 comments | Blog It | Email It | Keywords: genome evolution protein-coding gene genome assembly DNA genome Genome Biology codon usage optimization Neural Coding amino acid replacement amino acid

Genome 2.0:Mountains of new data are challenging old views

wugongliang submitted, created time 1 year 4 months (www.sciencenews.org)

When scientists unveiled a draft of the human genome in early 2001, many cautioned that sequencing the genome was only the beginning. The long list of the four chemical components that make up all the strands of human DNA would not be a finished book of life, but a road map of an undiscovered country that would take decades to explore.

1 comment | Blog It | Email It | Keywords: Human Genome Project DNA genome genome evolution

Enzymatic engineering of the porcine genome with transposons and recombinases

DanyC submitted, created time 1 year 5 months (www.biomedcentral.com)

"Researchers have demonstrated for the first time that vertebrate transposons and recombinases are capable of mobilizing DNA into and out of the porcine genome in a precise and efficient manner. This study provides the basis for developing transposon and recombinase based tools for genetic engineering of the swine genome."

Submit comment | Blog It | Email It | Keywords: genome evolution genome alignment DNA genome

Structure and evolution of a proviral locus of Glyptapanteles indiensis bracovirus

angelfish submitted, created time 1 year 6 months (www.biomedcentral.com)

"Contrary to current concepts of bracovirus proviral genome organization our results demonstrate that some but not all GiBV proviral segment sequences exist in a tandem array. Unexpectedly, non-coding DNA in the 8 proviral genome segments which typically occupies ~70% of BV viral genomes is under selection pressure suggesting it serves some function(s). We hypothesize that selection acting onproviral sequences maintains the genetic island-like nature of the cluster of proviral genome segments described herein

Submit comment | Blog It | Email It | Keywords: BVs genome evolution viral genome BV genomes GiBV

Principles of Genome Evolution in the Drosophila melanogaster Species Group

addict submitted, created time 1 year 7 months (biology.plosjournals.org)

"The mechanisms by which inversions are generated at the molecular level are poorly understood. The prevailing view involves the interactions of sequences that are moderately repeated in the genome. Here, we use molecular and computational methods to study 29 inversions that differentiate the chromosomes of three closely related fruit fly species."

Submit comment | Blog It | Email It | Keywords: Genome Evolution Drosophila melanogaster Species

Evolutionary Conservation of UTR Intron Boundaries in Cryptococcus

alpha submitted, created time 1 year 7 months (mbe.oxfordjournals.org)

"Despite significant progress, the general functional and evolutionary significance of the untranslated regions (UTRs) of eukaryotic transcripts remain mysterious. Particularly mysterious is the common occurrence of spliceosomal introns in transcript UTRs because UTR splicing is not necessary for restoration of transcript coding sequence. In general, it is not known to what extent such splicing performs an important function or merely represents spliceosomal "noise." We conducted the first analysis of evolutionary conservation of UTR splicing

Submit comment | Blog It | Email It | Keywords: untranslated regions genome evolution purifying selection

Genome evolution in major Escherichia coli O157:H7 lineages

Rhett submitted, created time 1 year 7 months (www.biomedcentral.com)

CGH data suggest the existence of two dominant lineages as well as LSPA type and PT-related subgroups within E. coli O157:H7. The genomic composition of these subgroups supports the phylogeny that has been inferred from other methods and further suggests that genomic divergence from an ancestral form and lateral gene transfer have contributed to their evolution. The genomic features identified in this study may contribute to apparent differences in the epidemiology and ecology of strains of different E. coli O157:H7 lineages.

Submit comment | Blog It | Email It | Keywords: genomic composition genome evolution lateral gene transfer