Heritability of alternative splicing in the human genome

angelfish submitted, created time 1 year 5 months (www.genome.org)

"Here researchers used pyrosequencing to map 40,569 unique sites of HIV integration. Computational prediction of nucleosome positions in target DNA indicated that integration sites are periodically distributed on the nucleosome surface, consistent with favored integration into outward-facing DNA major grooves in chromatin. Analysis of integration site positions in the densely annotated ENCODE regions revealed a wealth of new associations between integration frequency and genomic features."

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Mitochondrial DNA analysis of field populations of Helicoverpa armigera (Lepidoptera:Noctuidae) and of its relationship to H. zea

DanyC submitted, created time 1 year 5 months (www.biomedcentral.com)

"This mitochondrial DNA sequence data supports the single species status of H. armigera across Africa, Asia and Australia. The evidence for inter-continental gene flow observed in this study is consistent with published evidence of the capacity of this species to migrate over long distances. The finding of high genetic similarity between Old World H. armigera and New World H. zea emphasises the need to consider work on both pests when building pest management strategies for either."

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Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans

captainclaw submitted, created time 1 year 5 months (www.biomedcentral.com)

"Researchers findings provide tangible hints for elucidating the genetic basis of important phenotypic differences between these two streptomycetes. Importantly, absence of certain genes in S. lividans identified here could potentially explain the relative ease of DNA transformations and the conditional lack of actinorhodin synthesis in S. lividans."

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A novel technique for measuring variations in DNA copy-number: competitive genomic polymerase chain reaction

DanyC submitted, created time 1 year 6 months (www.biomedcentral.com)

”CGP is a moderate throughput technique for analyzing changes in genomic copy numbers. Because CGP can measure any genomic locus using PCR primers, it is especially useful for detailed analysis of a genomic region of interest.“

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Expandable DNA repeats and human disease

big pig submitted, created time 1 year 6 months (www.nature.com)

“Nearly 30 hereditary disorders in humans result from an increase in the number of copies of simple repeats in genomic DNA. These DNA repeats seem to be predisposed to such expansion because they have unusual structural features, which disrupt the cellular replication, repair and recombination machineries. The presence of expanded DNA repeats alters gene expression in human cells, leading to disease. Surprisingly, many of these debilitating diseases are caused by repeat expansions in the non-coding regions of their resident genes

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