sea-maid submitted, created time 6 months 3 weeks (www.jcb.org)

Mutant receptors made in one tumor cell can be passed to tumor cells lacking them.

In this study, the authors found that glioma cells expressing EGFRvIII transferred this errant receptor to nonexpressing cells via microvesicles--small plasma membrane buds. The microvesicles were produced in abundance by the mutant expressing cells and were widely taken up by receptor-negative cells

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MedUnion submitted, created time 1 year 2 weeks (www.mupnet.com)

AIM: Glioblastoma multiforme (GBM) is the most common primary brain tumor in humans, and it is highly invasive. Doxycycline, first identified as an antimicrobial agent, is a nonspecific inhibitor of matrix metalloproteinases (MMPs). Our objective was to investigate the anti-MMP effect of doxycycline at therapeutically acceptable levels on glioma cells in vitro.
METHODS: The MTT assay was used to determine the anti-proliferative effects of doxycycline. MMP2 activity and expression were determined by gelatinase zymo-graphy and real-time quantitative RT-PCR, respectively

Submit comment | Blog It | Email It | Keywords: matrix metalloproteinase 2 glioma cancer glioblastomas doxycycline