Neurodegenerative disease: Are amyloids the culprit?

sea-maid submitted, created time 2 months 4 days (www.nature.com)

Amyloid- (A) peptides are thought to have a key role in the neurotoxicity and cognitive decline that occur in Alzheimer's disease (AD), but there have recently been several disappointments with late-stage clinical trials of agents that target A. Two recent papers in Nature Medicine shed light on the mechanisms through which A could contribute to the aetiology of AD and identify novel targets for drug development, as well as compounds that modulate these targets.

One of the ways in which A is thought to contribute to the pathogenesis of AD is by disrupting mitochondrial function

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