Articles with the keyword: 
Metabolic correlates of subthalamic nucleus activity in Parkinson's disease
kavin submitted, created time 7 months 4 weeks (www.ncbi.nlm.nih.gov)
In this paper, the authors scanned 17 PD patients with (18)F-fluorodeoxyglucose (FDG) PET to measure resting glucose metabolism before the implantation of STN deep brain stimulation electrodes. The findings suggest that the functional pathways associated with motor disability in PD are linked to the STN firing rate. These pathways are likely to mediate the clinical benefit that is seen following targeted STN interventions for this disease. 
Gene Therapy Could Cure GSD-Ia
Sue Wu submitted, created time 9 months 3 weeks (www.dukemednews.org)
A gene therapy treatment that restores a missing liver enzyme in test animals could provide a cure for a rare metabolic disorder in humans, according to Duke University Medical Center researchers.
Novel genes 'notch' glucose into place
jane2007 submitted, created time 11 months 1 week (www.bcm.edu)
A novel gene called rumi regulates Notch signaling by adding a glucose molecule to the part of the Notch protein that extends outside a cell. It is also a key gene to specify neurons in the peripheral and central nervous system. When embryos lack a functional Notch protein, they have far too many neurons. The same phenomenon can be observed in rumi mutant embryos.
An Elevated Glucose Level Is A Strong Risk Factor For Colorectal Cancer
wugongliang submitted, created time 1 year 2 months (www.medicalnewstoday.com)
Diabetes is a very common illness that affects more than 20 million people in the U.S. and it is estimated an additional 54 million Americans have pre-diabetes, a condition that occurs when a person's blood glucose levels are higher than normal but not high enough for a diagnosis of type 2 diabetes. Therefore, it is important to determine whether glucose and insulin levels are associated with a higher risk of colon polyps, the precursor lesions to colon cancer
A mouse model of conditional lipodystrophy
stephen submitted, created time 1 year 2 months (www.pnas.org)
Lipodystrophies are syndromes of adipose tissue degeneration associated with severe defects in lipid and glucose homeostasis. We report here the generation and analysis of Ppargldi, a targeted allele that confers conditional dominant lipodystrophy in mice.
Smart Insulin Nanostructures Pass Feasibility Test, UT Study Reports
benjiamin submitted, created time 1 year 3 months (publicaffairs.uth.tmc.edu)
Biomedical engineers at the University of Texas School of Health Information Sciences at Houston have announced pre-clinical test results in the September issue of the International Journal of Nanomedicine demonstrating the feasibility of a smart particle insulin release system that detects spikes in glucose or blood sugar levels and releases insulin to counteract them
Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
sumsung submitted, created time 1 year 5 months (www.pnas.org)
In the fasted state, induction of hepatic glucose output and fatty acid oxidation is essential to sustain energetic balance. Production and oxidation of glucose and fatty acids by the liver are controlled through a complex network of transcriptional regulators.
Cholesterol drug hits diabetes with one-two punch, Tulane study says
bianjie submitted, created time 1 year 6 months (www.eurekalert.org)
Patients with type 2 diabetes may soon be able to control their glucose and their cholesterol levels with a single drug, according to a study led by Vivian A. Fonseca, professor of medicine and pharmacology at Tulane University School of Medicine and chief of the Tulane University Health Sciences Center Diabetes Program.
Glucose molecules 'seal' diabetes memory
gh0706 submitted, created time 1 year 6 months (www.sciencedaily.com)
British medical scientists have discovered how the body's metabolism is "locked" into a diabetic state after only limited high glucose exposure. The Warwick team, led by Dr. Antonio Ceriello, has proven the damage occurs during a process called glycation, when high glucose molecules bind with proteins in the mitochondria of cells -- the parts of cells governing the production and regulation of energy. The damage persists, even if glucose levels later fall to normal, and they said their finding confirms the need for very early tight control of glucose levels to avoid diabetic complication.
Pulling plastics from pulp -- biomass-based plastics become practical
Darkfrog submitted, created time 1 year 6 months (www.sciam.com)
Turning plant matter into new plastics has been possible for many years; it just hasn't been practical. The processes used to convert glucose to a base for plastics yields chunks of impurities. Using metal chlorides instead of acid catalysts, writes Scientific American, is up to 70% effective on glucose and 90% effective on fructose, both at temperatures of only 100C, as opposed to the 600C used in oil refining.
Full commercialization is still a few years off. This study comes out of the Pacific Northwest National Laboratory in Richland, Washington
crackpot submitted, created time 1 year 7 months (www.microbialcellfactories.com)
"Studies on aeration levels in pH controlled L. lactis spp. lactis batch cultures on glucose (55 mM) showed that product formation is extremely homolactic and the highest yield of lactate on glucose is obtained under microaerobic conditions (5% dissolved oxygen). Microaerobic conditions were therefore applied in experiments carried out to investigate the regulation of the uptake of glucose. The tool of glucostat fed-batch culture was employed, in which glucose was added at a rate suitable to maintain a stable concentration throughout the runs with glucose concentration ranging from 13
Regulation of Glucose Partitioning by PAS Kinase and Ugp1 Phosphorylation
athena submitted, created time 1 year 7 months (www.molecule.org)
"The ability of cells to recognize and respond to specific metabolic deficiencies is required for all forms of life. We have uncovered a system in the yeast S. cerevisiae that, in response to a perceived deficiency in cell wall glucan, alters partitioning of glucose toward glucan synthesis and away from glycogen synthesis. The paralogous yeast PAS kinases Psk1 and Psk2 phosphorylate UDP-glucose pyrophosphorylase (Ugp1), the primary producer of UDP-glucose, the glucose donor for glucan biosynthesis
High-Viscosity Hydroxypropylmethylcellulose Blunts Postprandial Glucose and Insulin Responses
amanda submitted, created time 1 year 7 months (care.diabetesjournals.org)
"High-viscosity hydroxypropylmethylcellulose (HV-HPMC) is a modified cellulose fiber that produces a viscous gel in the gastrointestinal tract. Clinical trials demonstrate that consumption of HV-HPMC significantly lowers cholesterol, but limited information has been available on the influence of HV-HPMC on postprandial insulin and glucose responses."
alpha submitted, created time 1 year 8 months (care.diabetesjournals.org)
"A combination of IV insulin (in the ICU) and SC insulin (outside the ICU), a less costly and less nursing-intensive therapy than 3 days of IV insulin postoperatively, results in a reduction of the increased surgical morbidity and mortality in diabetic patients after CT surgery. "
badboy submitted, created time 1 year 8 months (eurheartj.oxfordjournals.org)
"Among ACS patients, diabetes was associated with both greater inflammation and higher glucose levels and patients with both hyperglycaemia and inflammation had worse outcomes. Better control of both inflammation and hyperglycaemia should be assessed in future ACS trials as a means to reduce the cardiovascular risk among diabetics."
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