Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes

lewis submitted, created time 1 year 3 months (www.pnas.org)

Recent technical advances allow detection of several hundred volatile organic compounds (VOCs) in human exhaled air, many of which reflect unidentified endogenous pathways. Our group has previously estimated plasma glucose levels in healthy adults during a standard oral glucose tolerance test via exhaled VOC analysis.

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Glucose molecules 'seal' diabetes memory

gh0706 submitted, created time 1 year 6 months (www.sciencedaily.com)

British medical scientists have discovered how the body's metabolism is "locked" into a diabetic state after only limited high glucose exposure. The Warwick team, led by Dr. Antonio Ceriello, has proven the damage occurs during a process called glycation, when high glucose molecules bind with proteins in the mitochondria of cells -- the parts of cells governing the production and regulation of energy. The damage persists, even if glucose levels later fall to normal, and they said their finding confirms the need for very early tight control of glucose levels to avoid diabetic complication.

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