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A Sweet New Role for EGFR ...in Cancer!

jerry submitted, created time 7 months 4 weeks (www.cancercell.org)

The epidermal growth factor (EGFR) has served as an attractive bull's-eye for targeted cancer therapies.

Although the importance of EGFR as an oncogenic tyrosine kinase seems well established, this issue of Cancer Cell adds a new wrinkle to the role of EGFR in cancer. They find that this new function does not require EGFR kinase activity.

In this study, the authors demonstrate that EGFR facilitates glucose transport into cells by associating with and stabilizing a sodium/glucose cotransporter (SGLT1)

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