GAPDH and Autophagy Preserve Survival after Apoptotic Cytochrome c Release in the Absence of Caspase Activation

captainclaw submitted, created time 3 years 2 months (www.cell.com)

"In cells undergoing apoptosis, mitochondrial outer-membrane permeabilization (MOMP) is followed by caspase activation promoted by released cytochrome c. Although caspases mediate the apoptotic phenotype, caspase inhibition is generally not sufficient for survival following MOMP; instead cells undergo a “caspase-independent cell death” (CICD). Thus, MOMP may represent a point of commitment to cell death. Here, they identify glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a critical regulator of CICD

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