IgG glycan hydrolysis by a bacterial enzyme as a therapy against autoimmune conditions

davidd submitted, created time 8 months 3 days (www.pnas.org)

EndoS from Streptococcus pyogenes efficiently hydrolyzes the functionally important and conserved N-linked glycan of IgG in human blood. Repeated i.v. administration of EndoS in rabbits completely hydrolyzes the glycans of the whole IgG pool, despite the generation of anti-EndoS antibodies. EndoS administration had no apparent effects on the health of the animals

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Dolichol-linked oligosaccharide selection by the oligosaccharyltransferase in protist and fungal organisms

julie submitted, created time 1 year 7 months (www.jcb.org)

"The dolichol-linked oligosaccharide Glc3Man9GlcNAc2-PP-Dol is the in vivo donor substrate synthesized by most eukaryotes for asparagine-linked glycosylation. However, many protist organisms assemble dolichol-linked oligosaccharides that lack glucose residues."

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