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19

Beating heart tissue produced in laboratories

sea-maid submitted, created time 6 months 4 weeks (www.nature.com)

An international team of researchers has used stem cells to create heart tissue, complete with beat. By treating embryonic stem cells with growth factors, they coaxed them into becoming cardiovascular progenitor cells, which then developed into cardiomyocytes, vascular smooth muscle cells, and endothelial cells, which together form blood vessels. When injected into the hearts of mice with induced heart disease, they improve heart function.

What this discovery does not include is fibroblasts, the cells that form the framework of the heart.

9

A protein that makes breast cancer spread

jane2007 submitted, created time 8 months 1 week (www.nature.com)

A protein that determines whether breast cancer will spread and become deadly has been found. Monitoring for the protein could help patients to know how dangerous their cancer is before it spreads elsewhere and help them to decide which treatment to chose.

6

Gene Mutation Linked to Longer Life

Sue Wu submitted, created time 8 months 2 weeks (www.sciam.com)

A type of gene mutation long known to extend the lives of worms, flies and mice also turns up in long-lived humans. Researchers found that among Ashkenazi Jews, those who survived past age 95 were much more likely than their peers to possess one of two similar mutations in the gene for insulinlike growth factor 1 receptor (IGF1R).

12

Early Rise in Serum VEGF and PDGF Levels Predisposes Patients With a Normal MBL2 Genotype to Restenosis After Eversion Endarterectomy

Reviver submitted, created time 1 year 3 months (stroke.ahajournals.org)

"These findings indicate that the development of restenosis depends on both complement activation regulated by the MBL2 gene and pathologic processes leading to enhanced production of VEGF and PDGF during the very early postoperative period."

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