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13

Should healthy people take statins too?

sea-maid submitted, created time 5 days 9 hours (www.nature.com)

The results of a study examining whether a potent cholesterol-lowering drug decreases the risk of heart disease are out. Rosuvastatin was given to 17,802 seemingly healthy people, and their chance of developing heart problems plummeted. The results, published in the New England Journal of Medicine, have revealed a number of questions about how to prevent heart attacks. Is exercise and a low-fat diet enough, or should large swathes of the population be prescribed preventative medication? Nature News gets to the heart of the matter.

11

Mini heart attack best treated like the big one

sea-maid submitted, created time 1 week 3 days (www.sciencenews.org)

People who show up at a hospital with mild heart attack symptoms, but only ambiguous scores on medical tests, might still warrant emergency treatment, according to research presented at a meeting of the American Heart Association.

8

The Artificial Heart: Not Just a Pump

sea-maid submitted, created time 1 month 4 weeks (www.sciam.com)

In the late 1970's, both the medical community and the public were filled with optimism about the possibilities of medical science in general and the artificial heart project in particular. By the 1980's, the pendulum had swung the other way completely. This article is a colorful and well-written treatment of what happened in between to cause this change ...and what is happening now to bring it back.

7

Pollution from traffic "hinders heart pacing" in recent heart patients

jerry submitted, created time 2 months 1 week (news.bbc.co.uk)

Air pollution from traffic hinders the heart's ability to conduct electrical signals, a study has suggested. Exposure to small particulates - tiny chemicals caused by burning fossil fuels - caused worrying changes on the heart traces of forty-eight heart patients. Doctors are recommending that heart patients avoid driving and stay away from heavy traffic for a few days after surgery, but will that be enough?

13

Intracardiac septation requires hedgehog-dependent cellular contributions

kavin submitted, created time 6 months 1 week (www.ncbi.nlm.nih.gov)

The researchers use a genetic marker and novel magnetic resonance microscopy techniques to demonstrate the origins of the dorsal mesenchymal protrusion in the dorsal mesocardium, and its substantial contribution to atrioventricular septation. They demonstrate that Shh signaling is required within the dorsal mesocardium for its contribution to the atria. Failure of this addition results in severe AVSD. These studies demonstrate that AVSD can result from a primary defect in dorsal mesocardium, providing a new paradigm for the understanding of human AVSD.

13

Be still my beating stem cell heart

sea-maid submitted, created time 6 months 1 week (www.newscientist.com)

There's a new recipe in the embryonic stem cell cookbook. Scientists have announced the creation of a human master heart cell, able to transform into all the different cells that make up a beating heart. In this study, the scientists have begun experiments to transform iPS cells into the heart cells.

6

Can Seaweed Mend a Broken Heart?

Sue Wu submitted, created time 7 months 1 week (www.sciam.com)

New research indicates that an alginate-based biomaterial injected into heart attack victims may stave off further damage.

7

Cholesterol-Lowering Drug May Be Ineffective

jane2007 submitted, created time 7 months 3 weeks (sciencenow.sciencemag.org)

A study found that combining an effective older cholesterol drug, simvastatin, with the drug ezetimibe was no better than simvastatin alone in preventing arterial plaques--one of the goals of cholesterol-lowering treatment. This has raised questions about whether this purportedly cholesterol-lowering drug may not benefit heart health.

8

Technology Insight: magnetic navigation in coronary interventions

davidd submitted, created time 8 months 3 weeks (www.nature.com)

Magnetic navigation is rapidly emerging as a useful technology in the field of interventional cardiology. Precise control of the direction of a guide wire or a device in three-dimensional space offers a means to access vessels and areas of the heart that are often challenging to access with conventional methods. In this comprehensive Review, we detail the development of magnetic navigation technology and how this tool has been adapted for use during percutaneous coronary intervention

8

Tubercular myocarditis presenting with ventricular tachycardia

davidd submitted, created time 8 months 3 weeks (www.nature.com)

A previously fit and healthy 30-year-old man reported experiencing palpitations accompanied by nausea, sweating and presyncope. These symptoms were found to be associated with episodes of nonsustained ventricular tachycardia. The article represents the diagnosis and management of tubercular myocarditis.

5

Ghost heart has a tiny beat

jane2007 submitted, created time 10 months 1 week (www.nature.com)

This is a significant research that it will help thousands of people escape form cardiac tissue. Rat hearts, stripped of their cells by detergents, have been used as a scaffold to engineer a bioartificial heart, which can amazingly pump a little like the original organ. One day, it will be used to repair heart damage or even generate new hearts for transplantation.

7

A Link Between Anxiety and Heart Attacks

jane2007 submitted, created time 10 months 1 week (www.time.com)

It's no secret that men with angry, explosive personalities are at a higher risk of a heart attack. According to a new long-term study. Nervous, withdrawn and chronically worried people are courting coronary problems, too.So, be happy every second.

5

Man Receives Used Heart in Transplant

athena submitted, created time 1 year 6 months (hosted.ap.org)

"A civil engineer received a used heart that had been transplanted once before into a man who suffered non-heart-related complications during the procedure, hospital officials said Monday."

5

Mexican Boy Awaits Heart Replacement

julie submitted, created time 1 year 7 months (hosted.ap.org)

"An 8-year-old boy from northern Mexico is hospitalized in Arkansas awaiting a possible replacement for his diseased heart."

6

Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy

cappuccion submitted, created time 1 year 7 months (www.pnas.org)

" Cardiac hypertrophy is a common response to injury and hemodynamic stress and an important harbinger of heart failure and death. Herein, we identify the Kruppel-like factor 15 (KLF15) as an inhibitor of cardiac hypertrophy. Myocardial expression of KLF15 is reduced in rodent models of hypertrophy and in biopsy samples from patients with pressure-overload induced by chronic valvular aortic stenosis. Overexpression of KLF15 in neonatal rat ventricular cardiomyocytes inhibits cell size, protein synthesis and hypertrophic gene expression

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