Intracardiac septation requires hedgehog-dependent cellular contributions

kavin submitted, created time 7 months 4 weeks (www.ncbi.nlm.nih.gov)

The researchers use a genetic marker and novel magnetic resonance microscopy techniques to demonstrate the origins of the dorsal mesenchymal protrusion in the dorsal mesocardium, and its substantial contribution to atrioventricular septation. They demonstrate that Shh signaling is required within the dorsal mesocardium for its contribution to the atria. Failure of this addition results in severe AVSD. These studies demonstrate that AVSD can result from a primary defect in dorsal mesocardium, providing a new paradigm for the understanding of human AVSD.

Submit comment | Blog It | Email It | Keywords: AVSD magnetic resonance microscopu Shh hedgehog heart hedgehog-dependent cellular contribution Intracardiac septation

Hedgehog acts as a somatic stem cell factor in the Drosophila ovary

Darkfrog submitted, created time 1 year 10 months (www.columbia.edu)

It seems that the gene with the funny name -- hedgehog -- may have consequences for cell proliferation in drosophila, both in stem cells and cancers in humans.

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Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate

Vampire submitted, created time 1 year 10 months (www.nature.com)

Numerous microRNAs (miRNAs) have been discovered in the genomes of higher eukaryotes, and functional studies indicate that they are important during development. However, little is known concerning the function of individual miRNAs. We approached this problem in zebrafish by combining identification of miRNA expression, functional analyses and experimental validation of potential targets. We show that miR-214 is expressed during early segmentation stages in somites and that varying its expression alters the expression of genes regulated by Hedgehog signaling

Submit comment | Blog It | Email It | Keywords: Cell Therapeutics, Inc cell growth miR-214 eukaryote zebrafish Hedgehog