Influenza A Virus Neuraminidase Limits Viral Superinfection

sea-maid submitted, created time 6 months 2 weeks (jvi.asm.org)

Enveloped viruses use multiple mechanisms to inhibit infection of a target cell by more than one virion. These mechanisms may be of particular importance for the evolution of segmented viruses, because superinfection exclusion may limit the frequency of reassortment of viral genes.

In this study, the author shows that cellular expression of influenza A virus neuraminidase (NA), but not hemagglutinin (HA) or the M2 proton pump, inhibits entry of HA-pseudotyped retroviruses

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Flu hotspot found in Asia

jane2007 submitted, created time 7 months 5 days (www.nature.com)

Each year, officials struggle to predict which strains of flu will spread globally, killing up to 500,000. This year, the breeding ground for new influenza strains is centered in East and Southeast Asia.

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