Growing blood in a dish

sea-maid submitted, created time 5 months 2 weeks (www.nature.com)

Developing a way to reliably produce hematopoietic stem cells is a bloody tough problem. Unlike most tissues, cells of the hematopoietic system emerge from several embryonic sites and then circulate through the body. This mobility has perplexed researchers, who hope that mimicking the in vivo environment will help them culture these stem cells. Now, two British research teams report in Cell Stem Cell their complementary techniques for isolating these cells. These methods could form the lifeblood of creating easier alternatives to bone marrow transplantation.

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Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In Vivo

small melon submitted, created time 1 year 3 weeks (www.cancercell.org)

"A key characteristic of stem cells and cancer cells is their ability to self-renew. To test if Wnt signaling can regulate the self-renewal of both stem cells and cancer cells in the hematopoietic system, they developed mice that lack β-catenin in their hematopoietic cells. Here we show that β-catenin-deficient mice can form HSCs, but that these cells are deficient in long-term growth and maintenance

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Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis

sumsung submitted, created time 1 year 5 months (www.pnas.org)

Hematopoietic stem cells (HSC) produce all blood cell lineages by virtue of their capacity to self-renew and differentiate into progenitors with decreasing cellular potential. Recent studies suggest that epigenetic mechanisms play an important role in controlling stem cell potency and cell fate decisions.

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Donor-derived DNA in fingernails among recipients of allogeneic hematopoietic stem cell transplantation

Luneetty submitted, created time 1 year 7 months (bloodjournal.hematologylibrary.org)

"To examine whether donor-derived cells could exist in non-hematopoietic tissues of recipients after allogeneic hematopoietic stem cell transplantation, we examined the patterns of short tandem repeat (STR) of DNA extracted from fingernail clippings of recipients so that the contamination of blood cells was excluded. "

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Long-term monitoring of transplanted human neural stem cells in developmental and pathological contexts with MRI

annatto submitted, created time 1 year 7 months (www.pnas.org)

"Noninvasive monitoring of stem cells, using high-resolution molecular imaging, will be instrumental to improve clinical neural transplantation strategies. Researchers show that labeling of human central nervous system stem cells grown as neurospheres with magnetic nanoparticles does not adversely affect survival, migration, and differentiation or alter neuronal electrophysiological characteristics

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Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III

annatto submitted, created time 1 year 7 months (www.jci.org)

Single gene mutations in ß integrins can account for functional defects of individual cells of the hematopoietic system. In humans, mutations in ß2 integrin lead to leukocyte adhesion deficiency (LAD) syndrome and mutations in ß3 integrin cause the bleeding disorder Glanzmann thrombasthenia. However, multiple defects in blood cells involving various ß integrins (ß1, ß2, and ß3) occur simultaneously in patients with the recently described LAD type III (LAD-III)

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Regulation of B Versus T Lymphoid Lineage Fate Decision

big pig submitted, created time 1 year 7 months (www.sciencemag.org)

Hematopoietic stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate into B and T lymphocytes. Here scientists show that the proto-oncogene LRF plays an essential role in the B versus T lymphoid cell-fate decision. they demonstrate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage cells by repressing T cell–instructive signals produced by the cell-fate signal protein, Notch

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