From sequence to function: using RNAi to elucidate mechanisms of human disease

davidd submitted, created time 8 months 3 weeks (www.nature.com)

RNA interference (RNAi) has emerged as one of the most powerful tools for functionally characterizing large sets of genomic data. The capabilities of RNAi place it at the forefront of high-throughput screens, which are able to span the human genome in search of novel targets. The article assess the prospective applications of high-throughput screens, the data they are capable of generating, and the potential for this technique to further our understanding of human disease.

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