Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen

Cindy submitted, created time 1 year 9 months (bloodjournal.hematologylibrary.org)

It is reported here the identification of a novel HLA-B44-restricted minor histocompatibility antigen (mHA) with expression limited to hematopoietic cells. cDNA expression cloning studies demonstrated that the CTL epitope of interest was encoded by a novel allelic splice variant of HMSD, hereafter designated as HMSD-v. The immunogenicity of the epitope was generated by differential protein expression due to alternative splicing, which was completely controlled by one intronic single nucleotide polymorphism located in the consensus 5' splice site adjacent to an exon

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