Association with the Origin Recognition Complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p

jiangyun submitted, created time 1 year 2 months (www.biomedcentral.com)

Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 on histone H4.

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Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1

bianjie submitted, created time 1 year 5 months (www.pnas.org)

The polytene chromosomes of Drosophila melanogaster consist of condensed heterochromatin regions most of which are in the chromocenter, telomeres, and the fourth chromosome.

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Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells

sumsung submitted, created time 1 year 5 months (www.pnas.org)

Recent studies have suggested that, in ES cells, inactive genes encoding early developmental regulators possess bivalent histone modification domains and are therefore poised for activation. However, bivalent domains were not observed at typical tissue-specific genes.

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Transcriptional regulation by chromatin disassembly and reassembly

athena submitted, created time 1 year 8 months (www.sciencedirect.com)

"The packaging of the eukaryotic genome into chromatin severely restricts the access of the transcriptional machinery to the DNA. Recent studies reveal that histones are removed and replaced to enable or restrict, respectively, access of the transcription machinery to regulate transcription. Chromatin disassembly at promoters enables transcriptional activation, whereas promoter chromatin reassembly represses transcription."

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Signaling to the circadian clock: plasticity by chromatin remodeling

amanda submitted, created time 1 year 8 months (www.sciencedirect.com)

"How signaling influences chromatin remodeling through histone modifications is therefore highly relevant in the context of circadian oscillation. Recent advances in the field have revealed unexpected links between circadian regulators, chromatin remodeling and cellular metabolism. "

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Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation

athena submitted, created time 1 year 8 months (www.genesdev.org)

"Transcription by RNA polymerase II (polII) is accompanied by dramatic changes in chromatin structure. Numerous enzymatic activities contribute to these changes, including ATP-dependent nucleosome remodeling enzymes and histone modifying enzymes."

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Cooperative binding of the yeast Spt10p activator to the histone upstream activating sequences is mediated through an N-terminal dimerization domain

athena submitted, created time 1 year 9 months (nar.oxfordjournals.org)

"The yeast Spt10p activator is a putative histone acetyltransferase (HAT) possessing a sequence-specific DNA-binding domain (DBD) which binds to the upstream activation sequences (UAS elements) in the histone gene promoters. Spt10p binds to a pair of histone UAS elements with extreme positive cooperativity."

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Histone H3-K56 Acetylation Is Catalyzed by Histone Chaperone-Dependent Complexes

julie submitted, created time 1 year 9 months (www.molecule.org)

"We show here that H3-K56 acetylation is catalyzed when Rtt109, a protein that lacks significant homology to known acetyltransferases, forms an active complex with either of two histone binding proteins, Asf1 or Vps75. Rtt109 binds to both these cofactors, but not to histones alone, forming enzyme complexes with kinetic parameters similar to those of known histone acetyltransferase (HAT) enzymes. "

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The epigenetic regulation of mammalian telomeres

badboy submitted, created time 1 year 9 months (www.nature.com)

Epigenetic modifications are key players in the regulation of fly and yeast telomeres, and recent studies indicate that the same applies in mammalian cells. These findings have implications for our understanding of the roles of telomeres in ageing and cancer.

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Histone acetylation-independent transcription stimulation by a histone chaperone

julie submitted, created time 1 year 9 months (nar.oxfordjournals.org)

TAF-I remodel the chromatin structure through its interaction with the core domain of the histones, including the histone fold, and this mechanism is independent of the histone acetylation status.

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