Histone Crosstalk between H2B Monoubiquitination and H3 Methylation Mediated by COMPASS

kavin submitted, created time 1 year 3 weeks (www.cell.com)

"COMPASS, the yeast homolog of the mammalian MLL complex, is a histone H3 lysine 4 (H3K4) methylase consisting of Set1 (KMT2) and seven other polypeptides, including Cps35, the only essential subunit. Histone H2B monoubiquitination by Rad6/Bre1 is required for both H3K4 methylation by COMPASS, and H3K79 methylation by Dot1. However, the molecular mechanism for such histone crosstalk is poorly understood. Here, they demonstrate that histone H2B monoubiquitination controls the binding of Cps35 with COMPASS complex

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L3MBTL1, a Histone-Methylation-Dependent Chromatin Lock

annatto submitted, created time 1 year 6 months (www.cell.com)

"Distinct histone lysine methylation marks are involved in transcriptional repression linked to the formation and maintenance of facultative heterochromatin, although the underlying mechanisms remain unclear. We demonstrate that the malignant-brain-tumor (MBT) protein L3MBTL1 is in a complex with core histones, histone H1b, HP1γ, and Rb. The MBT domain is structurally related to protein domains that directly bind methylated histone residues

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Cancer epigenomics: DNA methylomes and histone-modification maps

channel submitted, created time 1 year 9 months (www.nature.com)

It is time to 'upgrade' cancer epigenetics research and put together an ambitious plan to tackle the many unanswered questions in this field using epigenomics approaches. An altered pattern of epigenetic modifications is central to many common human diseases, including cancer. Many studies have explored the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-gene basis; among their results has been the seminal finding of transcriptional silencing of tumour-suppressor genes by CpG-island-promoter hypermethylation

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