Articles with the keyword: 
International team tracks clues to HIV
piggy submitted, created time 1 year 3 months (www.rice.edu)
Rice University's Andrew Barron and his group, working with labs in Italy, Germany and Greece, have identified specific molecules that could block the means by which the deadly virus spreads by taking away its ability to bind with other proteins.
Using computer simulations, researchers tested more than 100 carbon fullerene, or C-60, derivatives initially developed at Rice for other purposes to see if they could be used to inhibit a strain of the virus, HIV-1 PR, by attaching themselves to its binding pocket. 
Nano-delivery could help tackle HIV
sea-maid submitted, created time 1 year 4 months (www.nature.com)
Biomedical engineers have found a way of safely delivering potentially therapeutic RNAs into vaginal cells using nanoparticles. The researchers hope similar particles could be used to make topical creams containing anti-HIV RNAs.
Re-awakening old genes to help in the fight against HIV
piggy submitted, created time 1 year 4 months (www.eurekalert.org)
A new vaginal cream containing a reawakened protein could someday prevent the transmission of HIV.
Scientists at the University of Central Florida in Orlando have revived a dormant gene found in humans and coaxed it to produce retrocyclin, a protein that resists HIV.
Lead scientist Alexander Cole used aminoglycosides, drugs commonly used to fight bacterial infections, to trigger the production of the sleeping protein expressed by the retrocyclin gene.
HIV Pays a Price for Invisibility
sea-maid submitted, created time 1 year 4 months (www.sciencedaily.com)
Mutations that help HIV hide from the immune system undermine the virus's ability to replicate, show an international team of researchers in the April 13 issue of the Journal of Experimental Medicine. The study was published online on March 23.
Some people have a type of human leukocyte antigen called HLA-B*5703, which is linked to T-cells that are quicker and more effective against HIV. However, the virus can quickly mutate three amino acids, rendering infected cells invisible to the body's immune system
Daily HIV/Aids Report Reviews Washington D.C.
sea-maid submitted, created time 1 year 5 months (allafrica.com)
This article talks about how the city of Washington D.C. has managed to reduce the spread of HIV within its limits. Washington D.C. has one of the highest HIV infection rates in the U.S. The article lauds needle exchange programs and a recent end to the Congressional ban on using public money to fund them, but insists that public awareness must be improved.
Potential new HIV drug may help patients not responding to other treatments
piggy submitted, created time 1 year 5 months (www.eurekalert.org)
This potential treatment for HIV may one day help people who are not responding to anti-retroviral therapy, suggests research due to be published tomorrow in the Journal of Immunology. Scientists looking at monkeys with the simian form of HIV were able to reduce the level of virus in the bloodstream to undetectable levels by adding a molecule called D-1mT to the monkeys' anti-retroviral therapy (ART).
Simian immunodeficiency virus (SIV) is very similar to the human immunodeficiency virus (HIV) and it is used to study the condition in animal models
Molecular farming becomes practical: One million doses of anti-HIV protein grown in plants
Darkfrog submitted, created time 1 year 5 months (www.nature.com)
1. It's a protein that interferes with HIV in human cell studies, probably by binding to the virus's surface. Unlike non-protein microbicides, it actually seems to work.
2. It was grown in plants. This means it would be cheap. Proteins of this kind are usually very expensive to mass-produce.
The genes coding for the protein were introduced into a type of tobacco plant called Nicotiana benthamiana using the tobacco mosaic virus. The protein itself is called griffithsin (GRFT), and is found in red algae
AIDS Drug Slows Spread of Deadly Childhood Brain Cancer
sea-maid submitted, created time 1 year 5 months (news.yahoo.com)
A drug approved to combat AIDS may also help slow the spread of a deadly type of brain tumor that tends to attack children.
Researchers progress toward AIDS vaccine
piggy submitted, created time 1 year 5 months (www.eurekalert.org)
Rutgers AIDS researchers Gail Ferstandig Arnold and Eddy Arnold may have turned a corner in their search for a HIV vaccine. In a paper just published in the Journal of Virology, the husband and wife duo and their colleagues report on their research progress.
With the support of the National Institutes of Health, the Arnolds and their team have been able to take a piece of HIV that is involved with helping the virus enter cells, put it on the surface of a common cold virus, and then immunize animals with it
Old Strategy for Tackling HIV Makes a Comeback
piggy submitted, created time 1 year 6 months (sciencenow.sciencemag.org)
For twenty years, AIDS researchers have searched for a vaginal microbicide that can block HIV, but they have made little progress. One gel has shown hints of working in a large-scale human study, but the rest have failed or even caused harm. Now a new monkey study suggests that a microbicide containing a compound that many investigators would consider old-fashioned may have the power to thwart the AIDS virus
Microbicide may prevent HIV from gaining a foothold in the body
Darkfrog submitted, created time 1 year 6 months (www.nature.com)
Glycerol monolaurate, a microbicide often used as an additive in foods and cosmetics, has been shown to protect female monkeys from contracting SIV, the simian equivalent of HIV. Ironically, it seems to work by suppressing the immune system.
During the early stages of HIV infection, the body musters an immune response to fight it off. Unfortunately for us, this immune response contains a significant does of CD4+ helper T-cells--the virus's favorite food. Suppress this immune response, and it may become harder for HIV to gain a foothold
HIV Adapts to Escape Immune Response
piggy submitted, created time 1 year 6 months (main.uab.edu)
A new study out of the University of Alabama at Birmingham (UAB) and Oxford University in England describes the human immunodeficiency virus's ability to adapt and avoid the human immune system. It spells out at least fourteen different changes, called escape mutations, that help keep itself alive after interacting genetically with the immunity molecules that would normally attack it.
The human immunodeficiency virus (HIV) adapts so well to the body's defense system that any successful AIDS vaccine must keep pace with the ever-changing immunological profile of the virus
HIV Is Evolving to Evade Human Immune Responses
sea-maid submitted, created time 1 year 6 months (www.sciencedaily.com)
HIV is evolving rapidly to escape the human immune system, an international study led by Oxford University has shown. The findings, published in Nature, demonstrate the challenge involved in developing a vaccine for HIV that keeps pace with the changing nature of the virus.
Stem cell transplant wipes out HIV
sea-maid submitted, created time 1 year 6 months (www.nature.com)
A man may have been cured of both HIV and leukemia after receiving a stem-cell transplant from a donor who is genetically resistant to HIV. Two years down the line, the patient has no detectable HIV virus in his system, even though he has stopped his regimen of antiretroviral drugs.
The mechanics of the treatment were no different from any other leukemia bone marrow transplant, which took place in Germany
Novel HIV-Fighting Method Finally Gels
piggy submitted, created time 1 year 6 months (sciencenow.sciencemag.org)
Trials of microbicide gels to protect women against HIV infection have a perfect record--not one of them has worked, and some were even harmful. But now a large international study has ended that curse, although the gel's benefits appear to be modest and require confirmation.
As reported here today at the 16th Conference on Retroviruses and Opportunistic Infections, the study showed that a microbicide called PRO 2000 reduced the risk of HIV infection by 30%
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