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ARF1 is directly involved in dynamin-independent endocytosis

DanyC submitted, created time 11 months 1 week (www.nature.com)

"Endocytosis of glycosylphosphatidyl inositol (GPI)-anchored proteins (GPI-APs) and the fluid phase takes place primarily through a dynamin- and clathrin-independent, Cdc42-regulated pinocytic mechanism. This mechanism is mediated by primary carriers called clathrin-independent carriers (CLICs), which fuse to form tubular early endocytic compartments called GPI-AP enriched endosomal compartments (GEECs)

Submit comment | Blog It | Email It | Keywords: homeostatic mechanisms homeostasis Cdc42 GPI culture-independent microbiology endocytosis

Homeostatic Mechanisms for Iron Storage Revealed by Genetic Manipulations and Live Imaging of Drosophila Ferritin

ocean submitted, created time 1 year 3 months (www.genetics.org)

“Ferritin is a symmetric, 24-subunit iron-storage complex assembled of H and L chains. It is found in bacteria, plants, and animals and in two classes of mutations in the human L-chain gene, resulting in hereditary hyperferritinemia cataract syndrome or in neuroferritinopathy. Fanis Missirlis et al examined systemic and cellular ferritin regulation and trafficking in the model organism Drosophila melanogaster. They showed that ferritin H and L transcripts are coexpressed during embryogenesis and that both subunits are essential for embryonic development

1 comment | Blog It | Email It | Keywords: Ferritin Homeostatic Mechanisms Drosophila