Liver X Receptor Activation Potentiates the Lipopolysaccharide Response in Human Macrophages

Reviver submitted, created time 1 year 3 months (circres.ahajournals.org)

"These data provide evidence for an immunomodulatory function of LXRs in human macrophages via mechanisms distinct from those previously identified in mouse macrophages."

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Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells

dovechocolate submitted, created time 1 year 7 months (www.pnas.org)

The human EGF receptor (HER) 2 receptor tyrosine kinase is a survival factor for human cardiomyocytes, and its inhibition may explain the increased incidence of cardiomyopathy associated with the anti-HER2 monoclonal antibody trastuzumab (Genentech, South San Francisco, CA), particularly in patients with prior exposure to cardiotoxic chemotherapies e.g., anthracyclines

Submit comment | Blog It | Email It | Keywords: human EGF receptor (HER) AMP-activated protein kinase (AMPK) cardiomyocytes