Articles with the keyword: 
Personal genomes: The case of the missing heritability
sea-maid submitted, created time 1 week 6 days (www.nature.com)
When scientists opened up the human genome, they expected to find the genetic components of common traits and diseases. But they were nowhere to be seen. Brendan Maher shines a light on six places where the missing loot could be stashed away. 
Discovery of natural compounds that could slow blood vessel growth
sea-maid submitted, created time 1 month 2 weeks (esciencenews.com)
Using a whole-genome approach, researchers have found more than one hundred human protein compounds that can slow blood vessel growth. This could lead to treatments against diseases that depend on the growth of new blood vessels, including cancer, macular degeneration and rheumatoid arthritis.
TGen investigators devise faster, cheaper way of analyzing the human genome
sea-maid submitted, created time 2 months 1 week (esciencenews.com)
Investigators at the Translational Genomics Research Institute (TGen) today announced a faster and less expensive way for scientists to find which genes might affect human health.
In Long-Awaited Maps of Cancer, the Breakthrough Is the Problem
jerry submitted, created time 2 months 2 weeks (online.wsj.com)
After struggling for years to improve the treatment of cancer, scientists now hope to fight the disease with the help of the same techniques that deciphered the human genome eight years ago: mapping it. The idea was to sort out which gene mutations cause which types of cancer so that cancer treatments could be tailored to each patient. However, what the researchers found was quite different...
Ethical treatment of whole genome research participants
Sue Wu submitted, created time 7 months 3 weeks (www.huliq.com)
Recent technological developments have made it possible for scientists to sequence an entire human genome, but these advances may be a mixed blessing.
Gene Mutation Linked to Longer Life
Sue Wu submitted, created time 8 months 2 weeks (www.sciam.com)
A type of gene mutation long known to extend the lives of worms, flies and mice also turns up in long-lived humans. Researchers found that among Ashkenazi Jews, those who survived past age 95 were much more likely than their peers to possess one of two similar mutations in the gene for insulinlike growth factor 1 receptor (IGF1R).
Eric wu submitted, created time 8 months 3 weeks (sciencenow.sciencemag.org)
Even with the entire human genome in hand, scientists can still have trouble rooting out the genes behind a disease. Consider amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. One ALS-related gene mutation was found in 1993, but it affects only 1% of all ALS patients. Now, after a long dry spell, researchers have finally hit on a second. It's just as rare as the first, but it seems to be more closely related to aspects of ALS pathology found in all patients.
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction
davidd submitted, created time 8 months 4 weeks (www.pnas.org)
Caloric restriction (CR) is the most potent intervention known to both protect against carcinogenesis and extend lifespan in laboratory animals. A variety of anticarcinogens and CR mimetics induce and activate the NF-E2-related factor 2 (Nrf2) pathway. Nrf2, in turn, induces a number of antioxidative and carcinogen-detoxifying enzymes. Thus, Nrf2 offers a promising target for anticarcinogenesis and antiaging interventions. They used Nrf2-disrupted (KO) mice to examine its role on the biological effects of CR
Illumina unveils genome sequence of African male
sumsung submitted, created time 9 months 6 days (www.nature.com)
Illumina, a biotechnology company based in San Diego, California, announced on 6 February that it has sequenced the complete genome of an African man. Scientists have already sequenced the genomes of two Caucasian men and one Chinese man, but Illumina's is the first African genome. It came from an anonymous Yoruban man from Nigeria.
Company claims to have sequenced man's genome cheaply
Sue Wu submitted, created time 9 months 1 week (www.nature.com)
A company based in San Diego, California, claims to have sequenced an individual human genome cheaper and faster than ever before.
Scientists Synthesize a Genome From Scratch
sumsung submitted, created time 9 months 4 weeks (sciencenow.sciencemag.org)
Researchers have rebuilt an entire genome from scratch, they report online today in Science. Although the team has yet to demonstrate that this DNA can substitute for the real thing, the work paves the way for customized bacteria that could efficiently produce drugs, biofuels, and other molecules useful to humankind.
1,000 Genomes Project: Expanding the Map of Human Genetics
sumsung submitted, created time 9 months 4 weeks (www.sciam.com)
The number of sequenced human genomes will soon swell to more than 1,000 as part of a new international research consortium's effort to trace the potential genetic origins of disease. But first the mother, father and adult child of a European-ancestry family from Utah and a Yoruba-ancestry family from Nigeria will join an anonymous individual as well as famous geneticists Craig Venter and James Watson as part of the handful of humans to have on record a complete readout of their roughly three billion pairs of DNA.
Culture Speeds Up Human Evolution
jane2007 submitted, created time 11 months 1 week (www.sciam.com)
Homo sapiens sapiens has spread across the globe and increased vastly in numbers over the past 50,000 years or so—from an estimated five million in 9000 B.C. to roughly 6.5 billion today. More people means more opportunity for mutations to creep into the basic human genome and new research confirms that in the past 10,000 years a host of changes to everything from digestion to bones has been taking place.
The article tell us the history of human evolution with the development of culture. In other word, human evolution affect by the nature and society culture.
The gene that turns breast-milk into brain food
yangjane submitted, created time 1 year 2 weeks (www.nature.com)
Only if the child carries a version of a gene that can harness the goodness of breast-milk, say researchers.
Which came first, the chicken genome or the egg genome?
scott submitted, created time 1 year 1 month (www.eurekalert.org)
Researchers have created the first evolutionary history of the duplications in the human genome that are partly responsible for both disease and recent genetic innovations. This work marks a significant step toward a better understanding of what genomic changes paved the way for modern humans, when these duplications occurred and what the associated costs are - in terms of susceptibility to disease-causing genetic mutations.
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