Mitochondrial p32 Is a Critical Mediator of ARF-Induced Apoptosis

kavin submitted, created time 4 months 4 weeks (www.cancercell.org)

The shared exon 2 of the p14ARF-p16INK4a locus is frequently mutated in human cancers. However, in contrast to the exon 1β-encoded N-terminal half of ARF, the function of the exon 2-encoded C-terminal half of ARF has been elusive. The authors report that the mitochondrial protein p32/C1QBP binds the ARF C terminus. They show that p32 is required for ARF to localize to mitochondria and induce apoptosis, and that ARF mutations specifically disrupting p32 binding can impair both of these functions

Submit comment | Blog It | Email It | Keywords: mitochondria Mitochondrial p32 apoptosis cell death human mitochondrial diseases ARF

Zebrafish to shed light on human mitochondrial diseases

yangjane submitted, created time 1 year 2 months (www.huliq.com)

"Mitochondrial impairments are emerging as important in many human diseases, but there have been few models for understanding exactly what is happening during the early development of the diseases," Guillemin said. "The use of mice is limited, because knocking out protein expression in mice mitochondria to mimic human-disease states results in large numbers of deaths in utero. Therefore, the symptoms that researchers have wanted to study have not been assessable in mice

1 comment | Blog It | Email It | Keywords: human mitochondrial diseases Zebrafish