Cancer Immunology Review

New Genetic Marker Characterizes Aggressiveness Of Cancer Cells

gh0706 submitted, created time 1 year 4 months (www.sciencedaily.com)

By suppressing genes that are active in the developing embryo, silenced just before birth, and re-activated years later in many advanced cancers, the let-7 family of "microRNAs"--tiny snippets of RNA that can put the brakes on expression of selected genes--appears to prevent human cancer cells from reasserting their prenatal capacity to divide rapidly, travel and spread. Peter and colleagues focused their initial studies on a standard panel, known as NCI60, of 60 human tumor cell lines that can genetically be divided into two large groups, which they called superclusters 1 and 2

Submit comment | Blog It | Email It | Keywords: microRNAs human renal cell cancer human renal cell carcinoma (RCC) HGMA2

In search of suitable reference genes for gene expression studies of human renal cell carcinoma by real-time PCR

Reviver submitted, created time 1 year 5 months (www.biomedcentral.com)

"This study demonstrated the suitability of the two housekeeping genes PPIA and TBP as endogenous reference genes when comparing malignant tissue samples with adjacent normal tissue samples from clear cell renal cell carcinoma. Both genes are recommended as reference genes for relative gene quantification in gene profiling studies either as single gene or preferably in combination. "

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A novel cell response triggered by interphase centromere structural instability

Reviver submitted, created time 1 year 5 months (www.jcb.org)

"Interphase centromeres are crucial domains for the proper assembly of kinetochores at the onset of mitosis. However, it is not known whether the centromere structure is under tight control during interphase. This study uses the peculiar property of the infected cell protein 0 of herpes simplex virus type 1 to induce centromeric structural damage, revealing a novel cell response triggered by centromere destabilization. It involves centromeric accumulation of the Cajal body–associated coilin and fibrillarin as well as the survival motor neuron proteins

Submit comment | Blog It | Email It | Keywords: cell-cycle-regulating protein human renal cell cancer Adult T-cell Leukemia (ATL) cells kinetochores

Does wyeth drug has small kidney cancer benefit

DanyC submitted, created time 1 year 5 months (uk.reuters.com)

According to a company-sponsored study. Treatment with Wyeth's drug temsirolimus, which secured U.S. regulatory approval on Wednesday, extended survival for 3 1/2 months for patients with advanced renal-cell carcinoma. Nearly 39,000 people are diagnosed in the United States with renal-cell carcinoma each year. Once the tumor has spread -- as it does in about one third of the patients -- there is usually no cure.

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Mouse FH knockout resembles human renal cell cancer

BIOBOSS submitted, created time 1 year 7 months (www.eurekalert.org)

A recurring single-nucleotide deletion in a heat-shock transcriptional promoter in the bacterial Buchnera symbiont of the pea aphid (Acyrthosiphon pisum) dramatically affects host fitness in a thermal-dependent manner.

Submit comment | Blog It | Email It | Keywords: Mouse FH knockout human renal cell cancer heat-shock transcriptional promoter Acyrthosiphon pisum