Adoptive transfer of T(reg) depleted autologous T cells in advanced renal cell carcinoma

Immunology submitted, created time 1 year 1 month (www.ncbi.nlm.nih.gov)

PURPOSE: CD4(+)CD25(+) regulatory T (T(reg)) cells are present in increased numbers in patients with advanced cancer and CD25(+) T cell depletion potentiates tumour immunity in animal models. The aim of this study was to assess the feasibility and safety of adoptive transfer of CD25(+) depleted autologous T cells in patients with advanced renal cell carcinoma and to examine resulting changes in lymphocyte subsets. PATIENTS AND METHODS: Six patients with advanced renal cell carcinoma underwent leukapheresis followed by conditioning chemotherapy with cyclophosphamide and fludarabine

Submit comment | Blog It | Email It | Keywords: T reg cell cancer toxicology renal cell carcinoma (RCC) human renal cell carcinoma (RCC)

CD4(+) T-cell recognition of human 5T4 oncofoetal antigen: implications for initial depletion of CD25(+) T cells

Immunology submitted, created time 1 year 1 month (www.ncbi.nlm.nih.gov)

BACKGROUND: The human 5T4 (h5T4) oncofoetal antigen is expressed by a wide variety of human carcinomas including colorectal, ovarian, gastric and renal, but rarely on normal tissues. Its restricted expression on tumour tissues as well as its association with tumour progression and bad prognosis has driven the development of a MVA-based vaccine (TroVax) which has been tested in several early phase clinical trials and these studies have led to the start of a phase III trial in renal cell carcinoma patients

Submit comment | Blog It | Email It | Keywords: kidneys RCC T-cells immunology cancer 5T4 T regulatory cells human renal cell carcinoma human renal cell carcinoma (RCC) CD4+ T cells

HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation

annatto submitted, created time 1 year 6 months (www.cancerci.com)

”These results indicate that HIF-2alpha regulation is not sufficient for pVHL-induced renal cell differentiation. We hypothesize that in addition to HIF-2alpha dysregulation, abrogation of additional pVHL functions is required for the initiation of renal carcinogenesis.“

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New Genetic Marker Characterizes Aggressiveness Of Cancer Cells

gh0706 submitted, created time 1 year 6 months (www.sciencedaily.com)

By suppressing genes that are active in the developing embryo, silenced just before birth, and re-activated years later in many advanced cancers, the let-7 family of "microRNAs"--tiny snippets of RNA that can put the brakes on expression of selected genes--appears to prevent human cancer cells from reasserting their prenatal capacity to divide rapidly, travel and spread. Peter and colleagues focused their initial studies on a standard panel, known as NCI60, of 60 human tumor cell lines that can genetically be divided into two large groups, which they called superclusters 1 and 2

Submit comment | Blog It | Email It | Keywords: microRNAs human renal cell cancer human renal cell carcinoma (RCC) HGMA2

In search of suitable reference genes for gene expression studies of human renal cell carcinoma by real-time PCR

Reviver submitted, created time 1 year 6 months (www.biomedcentral.com)

"This study demonstrated the suitability of the two housekeeping genes PPIA and TBP as endogenous reference genes when comparing malignant tissue samples with adjacent normal tissue samples from clear cell renal cell carcinoma. Both genes are recommended as reference genes for relative gene quantification in gene profiling studies either as single gene or preferably in combination. "

Submit comment | Blog It | Email It | Keywords: human renal cell carcinoma (RCC) Renal-Cell Carcinoma human renal cell cancer

Increased Expression of Vascular Endothelial Growth Factor in Kidney Leads to Progressive Impairment of Glomerular Functions

Reviver submitted, created time 1 year 7 months (jasn.asnjournals.org)

"Vascular endothelial growth factor (VEGF) is an important mediator in maintaining normal kidney functions. In addition, several lines of evidence suggest that upregulation of VEGF in glomeruli may be associated with or cause renal dysfunction such as diabetic nephropathy. For elucidation of the pathologic consequences of high levels of VEGF in glomeruli, transgenic (Tg) rabbits that express human VEGF165 isoform in both kidney and liver under the control of the human {alpha}-1-antitrypsin promoter were generated and characterized

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Does wyeth drug has small kidney cancer benefit

DanyC submitted, created time 1 year 7 months (uk.reuters.com)

According to a company-sponsored study. Treatment with Wyeth's drug temsirolimus, which secured U.S. regulatory approval on Wednesday, extended survival for 3 1/2 months for patients with advanced renal-cell carcinoma. Nearly 39,000 people are diagnosed in the United States with renal-cell carcinoma each year. Once the tumor has spread -- as it does in about one third of the patients -- there is usually no cure.

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Evidence for a Critical Role for Integrin-Linked Kinase and Nuclear Factor kappa B

addict submitted, created time 1 year 8 months (carcin.oxfordjournals.org)

"We have recently shown that parathyroid hormone-related protein (PTHrP), a cytokine-like polyprotein, is critical for human renal cell carcinoma (RCC) growth by inhibiting tumor cell apopotosis. Here we have explored mechanisms by which PTHrP controls tumor cell survival."

Submit comment | Blog It | Email It | Keywords: human renal cell carcinoma (RCC) parathyroid hormone-related protein (PTH