Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes

lewis submitted, created time 1 year 3 months (www.pnas.org)

Recent technical advances allow detection of several hundred volatile organic compounds (VOCs) in human exhaled air, many of which reflect unidentified endogenous pathways. Our group has previously estimated plasma glucose levels in healthy adults during a standard oral glucose tolerance test via exhaled VOC analysis.

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Normal relationship of beta and non-beta cells not needed for successful islet transplantation.

crackpot submitted, created time 1 year 6 months (diabetes.diabetesjournals.org)

"In mice implanted with beta cell enriched aggregates, the hyperglycemia was reversed and good graft function over a 12 week period was observed with regard to glucose and insulin levels, glucose tolerance tests and graft insulin content. The endocrine cell composition of the beta cell enriched aggregates remained constant; prior to and 12 weeks after transplantation the beta cell enriched aggregates comprised of 95% beta cells and 5% endocrine non beta cells

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PED/PEA-15 Regulates Glucose-Induced Insulin Secretion by Restraining Potassium Channel Expression in Pancreatic ß-Cells

alpha submitted, created time 1 year 9 months (diabetes.diabetesjournals.org)

"The phosphoprotein enriched in diabetes/phosphoprotein enriched in astrocytes (ped/pea-15) gene is overexpressed in human diabetes and causes this abnormality in mice. "

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