Fetal scalp sampling in labor--better for diagnosing hypoxia?

sea-maid submitted, created time 7 months 1 week (www.bmj.com)

Is scalp pH analysis more effective at diagnosing hypoxia in the fetus during labor than scalp lactate analysis? According to this randomised controlled multicenter trial of the two methods, acidemia at birth, operative interventions, low Apgar scores at five minutes, and admissions to neonatal intensive care units did not differ significantly. James P Neilson, professor of obstetrics and gynaecology, asks in an accompanying editorial if less invasive alternatives exist.

2 comments | Blog It | Email It | Keywords: human reproduction infants babies obstetrics childbirth birth hypoxia human development fetus Fetal surveillance

Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans

franklin submitted, created time 1 year 2 months (www.pnas.org)

The low barometric pressure at high altitude causes lower arterial oxygen content among Tibetan highlanders, who maintain normal levels of oxygen use as indicated by basal and maximal oxygen consumption levels that are consistent with sea level predictions.

2 comments | Blog It | Email It | Keywords: human culture science and culture genetic variants lungs breathing respiration race arterial oxygen blood circulating blood flow hypoxia

Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor

Reviver submitted, created time 1 year 5 months (www.pnas.org)

"Their data provide direct proof that DosS functions as a redox sensor, whereas DosT functions as a hypoxia sensor, and that O2, NO, and CO are modulatory ligands of DosS and DosT. Finally, they identified a third potential dormancy signal, CO, that induces the Mtb Dos regulon. They conclude that Mtb has evolved finely tuned redox and hypoxia-mediated sensing strategies for detecting O2, NO, and CO. Data presented here establish a paradigm for understanding the mechanism of bacilli persistence."

Submit comment | Blog It | Email It | Keywords: DosS functions Dos regulon Mtb Dos regulon Adenylate Sensor hypoxia hypoxia inducible factor 1 (HIF1)

Targeting the Nrf2-Prx1 Pathway with Selenium to Enhance the Efficacy and Selectivity of Cancer Therapy

Loss of Motor Control and/or Loss of Consciousness during Breath-Hold Competitions

angelfish submitted, created time 1 year 8 months (www.thieme-connect.com)

"Since the first official world championships in breath-hold diving (1996), a sport has developed where the athletes compete in various disciplines of breath-hold diving. One of the rules is that the diver should surface from a dive without showing any signs of hypoxia. Depending on the severity of hypoxia, a diver may suffer disqualifying signs such as loss of consciousness (LOC) or loss of motor control (LMC), the latter including signs such as confusion, affected postural control, spasms or speech problems

Submit comment | Blog It | Email It | Keywords: diving drowning hypoxemia hypoxia

Effects of a 28-Day “Living High - Training Low” on T-Lymphocyte Subsets in Soccer Players

angelfish submitted, created time 1 year 9 months (www.thieme-connect.com)

"The purpose of this study was to investigate the changes in T-lymphocyte subsets in soccer players during “living high - training low” (LHTL) for 28 days in comparison to equally trained control players. Sixteen male soccer players were randomly assigned into two groups. The LHTL group lived in normobaric hypoxic rooms, simulating an altitude of 3000 m for 10 hours per night for 28 days. The control group lived at sea level. Both LHTL and control groups trained together at sea level and completed the same training schedules

Submit comment | Blog It | Email It | Keywords: T-lymphocyte subsets hypoxia immune system