Dysgerminoma in three patients with Swyer syndrome

DanyC submitted, created time 1 year 6 months (www.wjso.com)

"In Patients with Swyer syndrome the risk of dysgerminoma is high and gonadectomy is recommended. Also 5% of dysgerminomas are discovered in phenotypic female and 46 XY karyotype, thus in adolescent with dysgerminoimas and amenorrhea, karyotype should be done."

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IFN{gamma} differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract

addict submitted, created time 1 year 8 months (bloodjournal.hematologylibrary.org)

Although proinflammatory cytokines are key mediators of tissue damage during graft-versus-host disease (GVHD), IFN{gamma} has previously been attributed with both protective and pathogenic effects. We have resolved this paradox by using wild type (wt), IFN{gamma}-/- and IFN{gamma}R-/- mice as donors or recipients in well described models of allogeneic stem cell transplantation (SCT). This is the result of direct effects on pulmonary parenchyma to prevent donor cell migration and expansion within the lung

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