Lymphomas can develop from B cells chronically helped by idiotype-specific T cells

athena submitted, created time 1 year 7 months (www.jem.org)

"B cell lymphomas have been associated with chronic infections and autoimmunity. However, most lymphomas develop in the absence of any known chronic antigenic stimulation. B cells process their highly diversified endogenous immunoglobulin and present clonally unique variable-region idiotypic (Id) peptides on their major histocompatibility complex (MHC) class II molecules to Id-specific T cells."

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