Articles with the keyword: 
Rheumatoid Arthritis Breakthrough
piggy submitted, created time 1 week 1 day (www.sciencedaily.com)
Rheumatoid arthritis is a painful, inflammatory type of arthritis that occurs when the body's immune system attacks itself. A new article reports a breakthrough in the understanding of how autoimmune responses can be controlled, offering a promising new strategy for therapy development for rheumatoid arthritis.
Normally, immune cells develop to recognise foreign material – antigens; including bacteria - so that they can activate a response against them. Immune cells that would respond to 'self' and therefore attack the body's own cells are usually destroyed during development 
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.
kavin submitted, created time 5 months 4 weeks (www.ncbi.nlm.nih.gov)
Here, researchers identify the Nalp3 inflammasome as a crucial element in the adjuvant effect of aluminium adjuvants; in addition, they show that the innate inflammasome pathway can direct a humoral adaptive immune response. This is likely to affect how we design effective, safe adjuvants in the future.
Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
carly submitted, created time 1 year 4 weeks (www.pnas.org)
UV radiation (UVR) is a complete carcinogen that elicits a constellation of pathological events, including direct DNA damage, generation of reactive oxidants that peroxidize lipids and damage other cellular components, initiation of inflammation, and suppression of the immune response.
Regulatory T cell-like responses in deer mice persistently infected with Sin Nombre virus
jimmy submitted, created time 1 year 2 months (www.pnas.org)
Hantavirus cardiopulmonary syndrome is a zoonotic illness associated with a systemic inflammatory immune response, capillary leak, noncardiogenic pulmonary edema, and shock in humans. Cytokines, including TNF, IFN-, and lymphotoxin, are thought to contribute to its pathogenesis.
Flies can turn off their immune response
bianjie submitted, created time 1 year 2 months (biology.plosjournals.org)
After a role in initiating an NF-mediated innate immune response to microbial challenge, AP-1 and STAT act to form part of a repressosome to down-regulate the transcription of antimicrobial peptides and thus to resolve the immune response.
Auto immune response creates barrier to fertility; could be a step in speciation
bianjie submitted, created time 1 year 2 months (www.eurekalert.org)
Plant biologists at the Max Planck Institute of Developmental Biology and the University of North Carolina at Chapel Hill have discovered that an autoimmune response, triggered by a small number of genes, can be a barrier to producing a viable offspring. This could be a newly identified step toward speciation.
Tai chi may boost immune response to flu shot
abc01 submitted, created time 1 year 2 months (www.reutershealth.com)
A preliminary study suggests, the traditional Chinese arts of tai chi and qigong may help boost older adults' immune response to the flu vaccine.
angelfish submitted, created time 1 year 3 months (genomebiology.com)
"Researchers show that ER negative basal breast cancer is a heterogeneous disease with at least four main subtypes. Furthermore we show that the heterogeneity in the clinical outcome of ER- breast cancer is related to the variability in expression levels of complement and immune response pathway genes independently of lymphocytic infiltration."
Scientists Discover Role Of Enzyme In DNA Repair
gh0706 submitted, created time 1 year 4 months (www.sciencedaily.com)
Scientists have made an important discovery about the role of an enzyme called ataxia telangiectasia mutated protein (ATM) in the body’s ability to repair damaged DNA. The focuses largely on certain genes that are deliberately broken and repaired as part of the immune response. The leader of the team hypothesized that once DNA lesions were generated, a regulatory activity would shut down transcription until repair enzymes corrected the damage. Because B lymphocyte cells are relatively scarce, they chose to focus their investigation on a more abundant family of genes as a substitute
Regulation of AID expression in the immune response
badboy submitted, created time 1 year 5 months (www.jem.org)
"The B cell–specific enzyme activation-induced cytidine deaminase (AID) has been shown to be essential for isotype switching and affinity maturation of antibody genes during the immune response. Conversely, AID activity has also been linked to autoimmunity and tumorigenesis. Determining how AID expression is regulated in vivo is therefore central to understanding its role in health and disease."
MedUnion submitted, created time 1 year 6 months (www.mupnet.com)
AIM: Dendritic cells (DCs) are potent antigen-presenting cells that play a pivotal role in regulating immune response in cancer. This study is to address whether irradiated prostate cancer cells have the capability to induce DCs to respond against a tumor.
METHODS: A highly tumorigenic mouse prostate tumor cell line RM-1 was subjected to gamma-irradiation and tested for induction of apoptosis by exploiting DNA analysis and Hoechst staining
athena submitted, created time 1 year 7 months (www.sciencedirect.com)
"B-1 cells comprise a small percentage of the B lymphocytes that reside in multiple tissues in the mouse, including the peritoneal and pleural cavities. Functionally, B-1 cells participate in innate immunity by producing the majority of the natural IgM in serum, which protects against invading pathogens before the onset of the adaptive immune response. B-1 cells arise from fetal and neonatal progenitors and are distinct from the adult bone marrow progenitors that give rise to follicular and marginal zone B-2 cells
fiona submitted, created time 1 year 7 months (www.sciencedirect.com)
"CD4+CD25+ regulatory T (Treg) cells have emerged as important regulators of immune responses but the mechanisms through which Treg cells mediate suppression are still unclear. "
badboy submitted, created time 1 year 8 months (www.sciencedirect.com)
"Here, the term ‘immune remodeling’ refers to these phenotypes that are indicative of biological processes of deterioration and repair. "
What's the role of IFN regulatory factor 5 transcription factor ?
saury submitted, created time 1 year 8 months (www.pnas.org)
“Host defense consists of two main aspects, namely, immune response to invading pathogens and suppression of tumor development. A family of transcription factors, IFN regulatory factors (IRFs), has recently gained much attention in terms of its critical role in linking these two aspects of host defense, wherein IRF5 was previously shown to play a critical role in the induction of proinflammatory cytokines by activation of Toll-like receptors. “
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