Cell-specific and efficient expression in mouse and human B cells by a novel hybrid immunoglobulin promoter in a lentiviral vector.

yangjane submitted, created time 1 year 3 months (www.ncbi.nlm.nih.gov)

We have constructed a novel enhanced B cell-specific promoter (Igk-E) consisting of an immunoglobulin kappa (Igk) minimal promoter combined with an intronic enhancer sequence and a 3' enhancer sequence from Ig genes.

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A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair

captainclaw submitted, created time 1 year 7 months (www.jem.org)

"Immunoglobulin class switch recombination (CSR) deficiencies are rare primary immunodeficiencies, characterized by a lack of switched isotype (IgG, IgA, or IgE) production, variably associated with abnormal somatic hypermutation (SHM). Deficiencies in CD40 ligand, CD40, activation-induced cytidine deaminase, and uracil-N-glycosylase may account for this syndrome. Researchers previously described another Ig CSR deficiency condition, characterized by a defect in CSR downstream of the generation of double-stranded DNA breaks in switch (S) µ regions

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Enhancement and suppression of signaling by the conserved tail of IgG memory–type B cell antigen receptors

fiona submitted, created time 1 year 8 months (www.jem.org)

"Immunological memory is characterized by heightened immunoglobulin (Ig) G antibody production caused in part by enhanced plasma cell formation conferred by conserved transmembrane and cytoplasmic segments in isotype-switched IgG B cell receptors."

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Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement

amanda submitted, created time 1 year 8 months (www.nature.com)

"The high frequency of immature and oligoclonal Ig/TCR rearrangements is probably caused by early (prenatal) oncogenic transformation in immature B-lineage progenitor cells with germline Ig/TCR genes combined with a short latency period."

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The pre-B-cell receptor

alpha submitted, created time 1 year 9 months (www.sciencedirect.com)

"The pre-B-cell receptor (pre-BCR) is composed of two immunoglobulin μ heavy chains and two surrogate light chains, which associate with the signaling molecules Igα and Igβ (Igα/β). The production of a functional pre-BCR is the first checkpoint in the current model of B-cell development. The pre-BCR mediates signals resulting in heavy chain allelic exclusion, down-regulation of the recombination machinery, developmental progression, VH repertoire selection, proliferation and down-regulation of the surrogate light chain genes

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