Articles with the keyword: 
Industry shifts focus to immunology and cancer
sea-maid submitted, created time 1 week 4 days (www.nature.com)
Economic factors, including competition from generic drugs, is hitting even the big pharmaceutical companies hard, reports Nature. In 2010, Pfizer's Lipitor enters the public domain. For these reasons, the larger companies are narrowing the focus of their research, hitting fewer diseases. They're also working on fewer primary care drugs and more drugs that would be prescribed by specialists, such as cancer drugs.
"When Wyeth Pharmaceuticals announced last week that it would cut some of its research and development (R&D) programs in women's health, the decision seemed counterintuitive 
How the Body Determines Optimal Amount of Germ-Fighting B Cells
piggy submitted, created time 1 week 5 days (www.sciencedaily.com)
Researchers at the University of Pennsylvania School of Medicine can now explain how the body determines whether there are enough mature B-cells in the blood stream at any one time. These are the cells that produce antibodies against germs to fight infections.
“There is a steady state number of B cells that is considered normal for humans,” says senior author Michael P. Cancro, PhD, Professor of Pathology and Laboratory Medicine
Key Gene May Be Crucial to Production of Thymus and Disease-Fighting T-cells
sea-maid submitted, created time 1 week 6 days (gopast.net)
This research provides the first evidence that a key gene may be crucial to maintaining the production of the thymus and its disease-fighting T-cells after an animal’s birth.
HIV vaccine failure explained?
sea-maid submitted, created time 2 weeks 2 days (www.nature.com)
Researchers have suggested that an experimental vaccine against AIDS might have failed in part because it made some people's immune cells more vulnerable to HIV infection.
Scientists turbo-charge immune cells to fight cancer
piggy submitted, created time 2 weeks 3 days (news.yahoo.com)
Scientists in the United States have created super-charged immune cells that helped beat back cancer tumors in half of a small group of patients tested, according to a study released Sunday.
Adding an artificial receptor to T-lymphocyte immune cells boosted their ability to fight a deadly form of cancer called neuroblastoma, the researchers reported.
Neuroblastoma attacks the nervous system. While fairly rare, it accounts for seven percent of all childhood cancers, and fifteen percent of non-adult cancer deaths
CD20 blockers eye crowded rheumatology market
sea-maid submitted, created time 1 month 2 days (www.nature.com)
When trial results for a novel cancer drug were trumpeted in July, the rheumatology field felt the ripples. The drug is ofatumumab, a monoclonal antibody (mAb) targeting the CD20 molecule on B lymphocytes. Its makers, London-based GlaxoSmithKline (GSK) and Genmab of Copenhagen, announced that the mAb had met its primary and secondary endpoints in chronic lymphocytic leukemia (CLL)
Can Mesenchymal Stem Cells Induce Tolerance to Cotransplanted Human Embryonic Stem Cells?
jerry submitted, created time 1 month 2 days (www.nature.com)
Mesenchymal stem cells (MSCs) are reported to be immune privileged. We assessed whether their transplantation (Tx) could create a suppressive microenvironment mitigating rejection of coinjected human embryonic stem cells (hESCs)...
New nano device detects immune system cell signaling
sea-maid submitted, created time 2 months 2 weeks (esciencenews.com)
Scientists have detected previously unnoticed chemical signals that individual cells use to communicate with each other over short distances. Minding the communiques of individual cells might not be so important for studying the heart or bones, but it is absolutely crucial to studying the immune system.
Genetically engineered tobacco plants used to grow anti-lymphoma vaccine
Darkfrog submitted, created time 3 months 4 weeks (www.sciam.com)
Reports in the Proceedings of the National Academy of Sciences report that an experimental vaccines has triggered the immune systems of eleven (out of sixteen) patients to attack their tumors. The patients are afflicted with what is called follicular B-cell lymphoma. Dangerous side effects? None.
The interesting part? The vaccine was grown courtesy of some genetically engineered tobacco plants.
Of course, all of the patients were also receiving chemotherapy at the time, so it may be difficult to tell which results may be attributed to the vaccine itself
kavin submitted, created time 4 months 4 weeks (content.nejm.org)
Much has been learned about the potential of the immune system to control cancer and the various ways that immunotherapy can boost the potential of the immune system for the benefit of the patient. This knowledge has stimulated the invention of many new therapeutic antibodies, cell-based treatments, and vaccines, which are starting to be used in clinical practice, either alone or in various combinations. These new therapies are expected to result in improved cancer treatment and, eventually, the prevention of cancer.
kavin submitted, created time 5 months 2 days (www.pnas.org)
Pituitary adenylate cyclase-activating peptide (PACAP), a cAMP-activating agent, is highly expressed in the hypothalamus during the period when many neuroendocrine cells become differentiated from the neural stem cells (NSCs). Activation of the cAMP system in rat hypothalamic NSCs differentiated these cells into β-endorphin (BEP)-producing neurons in culture
Foreign body reaction to biomaterials
jerry submitted, created time 5 months 4 days (www.sciencedirect.com)
The major focus of this review is on factors that modulate the interaction of macrophages and foreign body giant cells on synthetic surfaces where the chemical, physical, and morphological characteristics of the synthetic surface are considered to play a role in modulating cellular events.
the unleashed innate responses
sea-maid submitted, created time 5 months 3 weeks (www.pnas.org)
From this study, we know that neonates might suffer from the unleashed innate responses caused by an insufficient number of T cells, which leads to increased morbidity and mortality.
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.
kavin submitted, created time 5 months 4 weeks (www.ncbi.nlm.nih.gov)
Here, researchers identify the Nalp3 inflammasome as a crucial element in the adjuvant effect of aluminium adjuvants; in addition, they show that the innate inflammasome pathway can direct a humoral adaptive immune response. This is likely to affect how we design effective, safe adjuvants in the future.
Cytokines as Therapeutic Targets: Advances and Limitations
jerry submitted, created time 6 months 1 week (www.immunity.com)
Biological therapies targeting cytokines, T cells, or B cells have improved outcomes of inflammatory diseases. However, many issues remain open: What is the best target? How well can response be predicted? How can cure be achieved?
This article will answer these questions.
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