Cancer Immunology Review

Melanoma Cured 100% through Blood Cell Therapy

Molecular basis for passive immunotherapy of Alzheimer's disease

benjiamin submitted, created time 1 year 1 month (www.pnas.org)

Amyloid aggregates of the amyloid-β(Aβ) peptide are implicated in the pathology of Alzheimer's disease. Anti-Aβ monoclonal antibodies (mAbs) have been shown to reduce amyloid plaques in vitro and in animal studies.

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Treating hay fever prevents asthma in some kids

DanyC submitted, created time 1 year 3 months (www.reutershealth.com)

Researchers say, children who suffer from hay fever, due to allergies to mold or pollen, are less likely to go on to develop asthma if they get immunotherapy to combat their sensitivity to allergy-triggers.

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Prospects for the use of NK cells in immunotherapy of human cancer

sciencebaby submitted, created time 1 year 6 months (www.nature.com)

Current insights into the molecular specificities that regulate natural killer (NK)-cell function suggest that it might be possible to design NK-cell-based immunotherapeutic strategies against human cancer. Here, we describe evidence for NK-cell targeting of human tumours and address crucial questions that, in our opinion, require consideration for the development of successful NK-cell-based therapies. Appropriately used, we predict that NK cells will have a role, both directly and in combination with other treatment modalities, in future treatment of cancer.

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Alternative splicing due to an intronic SNP in HMSD generates a novel minor histocompatibility antigen

Cindy submitted, created time 1 year 7 months (bloodjournal.hematologylibrary.org)

It is reported here the identification of a novel HLA-B44-restricted minor histocompatibility antigen (mHA) with expression limited to hematopoietic cells. cDNA expression cloning studies demonstrated that the CTL epitope of interest was encoded by a novel allelic splice variant of HMSD, hereafter designated as HMSD-v. The immunogenicity of the epitope was generated by differential protein expression due to alternative splicing, which was completely controlled by one intronic single nucleotide polymorphism located in the consensus 5' splice site adjacent to an exon

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T-regulatory cells are relatively deficient in squamous carcinomas undergoing regression in mice immunized with a squamous carcinoma vaccine enriched for immunotherapeutic cells

addict submitted, created time 1 year 7 months (www.nature.com)

In a prior report the scientists described a new vaccination strategy for squamous cell carcinoma (SCC). The vaccine was prepared by transfer of unfractionated DNA-fragments (25 kb) from KLN205 cells, a squamous carcinoma cell line (DBA/2 origin; H-2d) into LM cells, a highly immunogenic mouse fibroblast cell line (C3H/He origin; (H-2k))

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