Articles with the keyword: 
Darkfrog submitted, created time 1 week 3 days (www.nature.com)
Researchers from Harvard have found that using adenoviruses to reprogram cells can avoid some of the risk of making induced pluripotent stem cells. Instead of integrating into the host cell's DNA, the adenoviruses express the genes themselves.
So far, the experiments have only been successful in mouse tail and liver cells, which are much less hard to work with than primate cells and tissues. In addition, the overall success rate is much lower than that of integrating virus methods, reprograming cells only 0.0001% to 0.001% of the time 
Induced stem cell lines may soon be available from Harvard
Darkfrog submitted, created time 1 month 4 weeks (sciencenow.sciencemag.org)
A few weeks ago, we talked about how researchers had been able to take a cell from an ALS patient and develop a working, research-quality pluripotent cell line. Well the next step has been taken.
I've been saying that induced pluripotent stem cells might become the preferred research model (over embryonic stem cells), but only if they became easier to obtain than embryonic stem cells. It looks as though that might happen soon. The Harvard Stem Cell Institute is dedicating an iPS core lab
Induced stem cells become research model for ALS
Darkfrog submitted, created time 2 months 5 days (sciencenow.sciencemag.org)
Induced stem cells are coming into their own as a research model. Scientists at Harvard and Columbia have created a culture of motor cells from the skin of a patient known to be afflicted with amyotropic lateral sclerosis, also known as Lou Gherig's disease.
The patient has a rare form of ALS that is known to be caused by an inherited mutation. This represents only 2% of ALS patients. This may be significant because critics claim that partial replicants of the patient's nerve cells will be of little use as research models
Stem cell meeting 2008: complications for induced pluripotent stem cells
sea-maid submitted, created time 2 months 1 week (www.nature.com)
This year's meeting of the International Society for Stem Cell Research in Philadelphia, Pennsylvania, included a jam-packed session on the standards and methodologies of creating induced pluripotent stem cells. But although excitement around advances in reprogramming somatic cells shows no signs of abating, new ideas regarding the field are surfacing.
One announcement in particular may have consequences for induced pluripotent stem cells: It seems that ever reprogrammed cells can retain some echoes of their differentiated states, which researchers have nicknamed "cellular memory
Stem cells: One more roadblock removed from the path to practical induced pluripotency
Darkfrog submitted, created time 3 months 3 days (blog.wired.com)
This team from the Whitehead Institute for Biological Research has moved induced pluripotent stem cells one step closer to maturity. Using a two-pronged approach, they used a virus to insert the genes into mouse cells, but employ a drug to switch them on and off. This makes hte cells less likely to turn cancerous. The process is written up in Nature Biotechnology. Unlike previous iPS techniques, this produces a culture of genetically identical cells, something that iPS to date had not yet been able to do
Zinc-finger proteins turn T-cells HIV-resistant
Darkfrog submitted, created time 3 months 4 days (www.nature.com)
ZInc-finger proteins occur naturally in human cells and regulate gene activity. Researchers out of California's Sangamo Biosciences have figured out how to use these proteins to disrupt and disable specific genes. The kicker? When the gene in question is CCR5, human T-cells suddenly become resistant to infection with HIV.
At this point, any practical treatment would involve removing (or growing) the patient's own T-cells, treating them with zinc finger proteins, and then re0injecting the patient. Cumbersome, but possible
UGA research may lead to safer, more effective gene therapy
sea-maid submitted, created time 3 months 1 week (esciencenews.com)
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps...
sea-maid submitted, created time 3 months 1 week (www.nature.com)
In this study, the author provide new strategies which could lead to changes in the quality, quantity of induced pluripotent cells.
Stem Cell Question Grows Still Gnarlier
Sue Wu submitted, created time 7 months 3 days (discovermagazine.com)
In his January 2008 State of the Union address, President George W. Bush claimed that research by James Thomson of the University of Wisconsin and Shinya Yamanaka of the University of Kyoto in Japan would finally end the morally and politically nettlesome debate over embryonic stem cell research.
UCLA joins skin-to-stem-cell club
Sue Wu submitted, created time 7 months 3 weeks (www.efluxmedia.com)
US scientists said they have successfully reprogrammed human skin cells to behave exactly as embryonic stem cells. The research was published in the Feb. 11 edition of the journal Proceedings of the National Academy of the Sciences. This is the third such confirmation that the technique is feasible
Human Embryos Cloned From Skin Cells
Eric wu submitted, created time 8 months 2 weeks (sciencenow.sciencemag.org)
A new breakthrough on stem-cell research!
A major breakthrough occurred last year when scientists figured out how to turn skin cells into ES-like cells. But they still want to be able to do cloning, otherwise known as somatic cell nuclear transfer (SCNT), because embryonic cells are the "gold standard" for pluripotent cells--cells that can become any cell type in the body. In addition, scientists want to learn more about how an oocyte can reprogram a mature cell back into an ES cell.
Decelluarization:New hope may lie in lab-created heart
DanyC submitted, created time 8 months 3 weeks (edition.cnn.com)
Creating a replacement heart for some of the sickest patients may be one step closer, if new research in rats pans out in humans, and the new research is "exciting and has enormous potential, but clearly more needs to be done.
Building a New Heart From Old Tissue
Eric wu submitted, created time 8 months 3 weeks (sciencenow.sciencemag.org)
Approximately 3000 patients in the United States are on the waiting list for a heart transplant, but only about 2000 donor organs become available each year.
This article put forward a new method to solve the life-and-death problem.It includes two pivotal factors:The first one is that we need to find an appropriate stem cell that can give rise to heart tissue;The second one is that the cells require a framework, or scaffolding, to grow on.
Do you think it is feasible to resolve the difficult medical problem?
Discovery in rat hearts could lead to tailored transplants
Darkfrog submitted, created time 8 months 3 weeks (www.nature.com)
A few years back, I described induced pluripotent stem cells as "the holy grail." This is what stem cell researchers were looking for: a way to produce rejection-proof cells specifically tailored to the patient's system. However, stem cells still can't be grown into organs all by themselves -- we can make liver tissue but we can't make a liver. They need a frame upon which to grow.
And some guys from the University of Minnesota just found out how to get one.
Good News: Stem Cells Overpower Muscle Disease
Eric wu submitted, created time 9 months 3 weeks (sciencenow.sciencemag.org)
The recent breakthrough of skin cells reprogrammed to behave like embryonic stem cells has stolen the spotlight (ScienceNOW, 6 December), but adult stem cells are proving that they have advantages of their own. In the 13 December issue of Cell Stem Cell, researchers report using stem cells from patients afflicted with a form of muscular dystrophy to correct the disorder in mice. The results suggest that this strategy could one day treat muscular dystrophy in humans as well as other genetic disorders.
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