Optimizing the Dose of Pre-Pandemic Influenza Vaccines to Reduce the Infection Attack Rate

addict submitted, created time 1 year 6 months (medicine.plosjournals.org)

The recent spread of avian influenza in wild birds and poultry may be a precursor to the emergence of a 1918-like human pandemic. Therefore, stockpiles of human pre-pandemic vaccine (targeted at avian strains) are being considered. For many countries, the principal constraint for these vaccine stockpiles will be the total mass of antigen maintained. We tested the hypothesis that lower individual doses (i.e

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