Articles with the keyword: 
Men who take aspirin have significantly lower PSA levels
sea-maid submitted, created time 4 days 22 hours (www.genengnews.com)
The use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) is significantly associated with lower PSA levels, especially among men with prostate cancer, say researchers at Vanderbilt University. 
How Eating Red Meat Can Spur Cancer Progression: New Mechanism Identified
piggy submitted, created time 1 week 23 hours (www.sciencedaily.com)
Researchers at the University of California, San Diego School of Medicine, led by Ajit Varki, M.D., have shown a new mechanism for how human consumption of red meat and milk products could contribute to the increased risk of cancerous tumors.
Their findings, which suggest that inflammation resulting from a molecule introduced through consumption of these foods could promote tumor growth, are published online this week in advance of print publication in the Proceedings of the National Academy of Sciences (PNAS)
kavin submitted, created time 4 months 2 weeks (www.medscape.com)
This large, prospective, observational study showed that Finnish smokers who consumed eight or more cups of coffee per day had a 23% lowered risk for cerebral infarction, whereas those who drank two or more cups of black tea daily had a 21% lowered risk for this type of stroke vs those who drank little or none of these beverages. The associations were independent of risk factors such as a history of coronary heart disease.
Their report is published in the June 2008 issue of Stroke
Blood stem cells triggered by inflammation may protect neurons
jane2007 submitted, created time 6 months 4 weeks (news-service.stanford.edu)
Chronic inflammation triggers bone marrow-derived blood cells to travel to the brain and fuse with a certain type of neuron up to 100 times more frequently than previously believed, according to a new study.
The IB kinase – a bridge between inflammation and cancer
davidd submitted, created time 8 months 2 weeks (www.nature.com)
A potential link between inflammation and cancer has been suspected for over a century, but the exact molecular mechanisms connecting the two remained nebulous. The review proposed that NF-B transcription factors regulated via the IB kinase (IKK) complex play a critical role in coupling inflammation and cancer and have set out to test this hypothesis in mouse models of cancer.
davidd submitted, created time 9 months 3 weeks (genomebiology.com)
Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly involved in activating inflammatory processes and altering cell composition in white adipose tissue (WAT). Here, they analyzed the transcriptomic signature of the WAT in obese human subjects, in stable weight conditions and after weight loss following bariatric surgery.
Sue Wu submitted, created time 11 months 1 week (discovermagazine.com)
Jim Hammond is an elite athlete. He works out two hours a day with a trainer, pushing himself through sprints, runs, and strength-building exercises. His resting heart rate is below 50. He’s won three gold medals and one silver in amateur competitions this year alone, running races from 100 to 800 meters. In his division, he’s broken four national racing records. But perhaps the most elite thing about Hammond is his age.
Peptidase frees receptors in endosomes
dedu submitted, created time 11 months 2 weeks (www.jcb.org)
“Internalized pain receptors are freed up by a peptidase for another round of agony, Padilla et al. reveal.
Peptidases on the cell surface cleave and thereby activate or inactivate small, extracellular peptides such as angiotensin. The enzymes also reside in internal compartments called endosomes, where their action is less apparent.
The new work shows that a peptidase called ECE-1 needs the low pH of the endosome to cleave several of its targets. One such peptide target was CGRP, which is released by cells during inflammation
jiangyun submitted, created time 1 year 2 months (carcin.oxfordjournals.org)
Our data provide new insight into the mechanism by which n-3 PUFA suppress tumorigenesis through dampening of inflammation and NF-B activity. These results support a protective role of n-3 PUFA supplementation in the prevention of colorectal cancer.
ealnemri submitted, created time 1 year 2 months (www.nature.com)
This article describes the discovery and characterization of the pyroptosome. The pyroptosome mediates an inflammatory form of cell death called pyroptosis through activation of caspase-1. The pyroptosome is composed of oligomerized dimers of the adaptor protein ASC. The pyroptosome is assembled in macrophages, monocytes and perhaps other cell types containing ASC in response to stimulation with intracellular potassium-depleting agents.
Scarlett submitted, created time 1 year 4 months (www.lipidworld.com)
LPC concentrations were decreased in cancer patients. LPC plasma concentrations correlated with weight loss and inflammatory parameters and, therefore, might be a general indicator of severity of malignant disease.
Research suggests fitness reduces inflammation
bianjie submitted, created time 1 year 4 months (www.news.uiuc.edu)
A number of studies have suggested that regular exercise reduces inflammation -- a condition that is predictive of cardiovascular and other diseases, such as diabetes. If such a link exists, the nature of the relationship is by no means fully understood. A recent study by researchers at the University of Illinois provides new evidence that may help explain some of the underlying biological mechanisms that take place as the result of regular exercise.
tejpareek submitted, created time 1 year 5 months (www.pnas.org)
This research provides new insights about molecular mechanism of pain signaling. By using different functional genomics tools authors have established a novel potential role of Cdk5/p35 in pain signaling. This discovery provides new hopes for development of more potent analgesics drugs targeted for Cdk5 signaling.
amanda submitted, created time 1 year 6 months (eurheartj.oxfordjournals.org)
"L-NMMA resulted in modest increases in MAP at 15 min compared with placebo but there were no differences at 2 h. "
Deletion of the phosphoinositide 3-kinase p110{gamma} gene attenuates murine atherosclerosis
addict submitted, created time 1 year 6 months (www.pnas.org)
"Inflammatory cell activation by chemokines requires intracellular signaling through phosphoinositide 3-kinase (PI3-kinase) and the PI3-kinase-dependent protein serine/threonine kinase Akt. Atherosclerosis is a chronic inflammatory process driven by oxidatively modified (atherogenic) lipoproteins, chemokines, and other agonists that activate PI3-kinase. Here we show that macrophage PI3-kinase/Akt is activated by oxidized low-density lipoprotein, inflammatory chemokines, and angiotensin II."
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