Cytokines as Therapeutic Targets: Advances and Limitations

jerry submitted, created time 7 months 3 weeks (www.immunity.com)

Biological therapies targeting cytokines, T cells, or B cells have improved outcomes of inflammatory diseases. However, many issues remain open: What is the best target? How well can response be predicted? How can cure be achieved?
This article will answer these questions.

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Whole grains may cut risk of inflammatory diseases

annatto submitted, created time 1 year 6 months (www.reutershealth.com)

The health benefits of whole grains may extend beyond the heart, according to a new study that links the foods to a lower risk of inflammatory conditions such as arthritis or asthma.

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MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment

cappuccion submitted, created time 1 year 8 months (www.nature.com)

The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. Here they identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF. MIF triggered Galphai- and integrin-dependent arrest and chemotaxis of monocytes and T cells, rapid integrin activation and calcium influx through CXCR2 or CXCR4. MIF competed with cognate ligands for CXCR4 and CXCR2 binding, and directly bound to CXCR2

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