TIPE2, a Negative Regulator of Innate and Adaptive Immunity that Maintains Immune Homeostasis

kavin submitted, created time 6 months 2 weeks (www.cell.com)

It is known that immune homeostasis is essential for the normal functioning of the immune system, and its breakdown leads to fatal inflammatory diseases. In this paper, the authors found that TIPE2 is an essential negative regulator of TLR and TCR function, and its selective expression in the immune system prevents hyperresponsiveness and maintains immune homeostasis.

3 comments | Blog It | Email It | Keywords: TLR TCR homeostasis negative feedback TIPE2 Immune Function Immune System Enzyme mammalian immune system immune system innate immune system TIPE2 Immune Homeostasis

Caspase-1 inflammasomes: choosing between death and taxis

moonshine submitted, created time 1 year 2 months (www.nature.com)

Among the arsenal of the innate immune system are the Nod-like receptors (NLRs), which detect intracellular pathogens or other 'alarms' and participate in the formation of the inflammasome, an oligomeric platform that dimerizes and thereby activates caspase-1. The caspase, in turn, processes pro-IL1 and pro-IL18, key cytokines for the recruitment and engagement of inflammatory cells (hence, 'taxis'). But the activation of caspase-1 can also trigger a form of cell death with characteristics of necrosis and apoptosis that has been called 'pyroptosis'

1 comment | Blog It | Email It | Keywords: Caspase-1 Activation caspase-14 protein initiator caspase caspase B-cell activation innate immune system Cell death

Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin

sumsung submitted, created time 1 year 3 months (www.pnas.org)

We have tested a hypothesis that the natural product curcuminoids, which has epidemiologic and experimental rationale for use in AD, may improve the innate immune system and increase amyloid- (A) clearance from the brain of patients with sporadic Alzheimer's disease (AD).

Submit comment | Blog It | Email It | Keywords: innate immune system Alzheimers disease AD